Rhizopus-host interplay of disseminated mucormycosis in immunocompetent mice

Autor(es):Mostrar menos -

dos Santos, Amanda R. ^[1] ; Fraga-Silva, Thais F. ^[2] ; Almeida, Debora de Fatima ^[1] ; dos Santos, Rodolfo F. ^[1] ; Finato, Angela C. ^[1] ; Amorim, Barbara C. ^[1] ; Andrade, I, Maria ; Soares, Cleverson T. ^[3] ; Lara, Vanessa S. ^[4] ; Almeida, Nara L. M. ^[4] ; de Arruda, Olavo S. ^[1] ; de Arruda, Maria S. P. ^[1] ; Venturini, James ^{[1, 5]}

Afiliação do(s) autor(es)

^[1] Univ Estadual Paulista, Fac Ciencias, UNESP, BR-17033360 Bauru, SP - Brazil

^[2] Univ Estadual Paulista, Inst Biociencias, UNESP, BR-18618689 Botucatu, SP - Brazil

^[3] Andrade, Maria, I, Lauro de Souza Lima Inst, BR-17034971 Bauru, SP - Brazil

^[4] Univ Sao Paulo, Fac Odontol Bauru FOB, BR-17012901 Bauru, SP - Brazil

^[5] Univ Fed Mato Grosso do Sul UFMS, Fac Med, BR-79070900 Campo Grande, MS - Brazil

• Tipo de documento: Artigo Científico
• Fonte: FUTURE MICROBIOLOGY; v. 15, n. 9, p. 739-752, JUN 2020.
• Citações Web of Science: 0

Resumo

Aim: To investigate the immune response of disseminated Ryzopus oryzae infection in immunocompetent mice. Methods: C57Bl/6, BALB/c and Swiss wild-type mice were intravenously infected with R. oryzae; the parameters of infection and immune response were determined. Transcriptional signature of Th17 immune response and infection in Il17ra(-/-) mice were also evaluated. Results: All mouse strains showed an initial spread of R. oryzae in the target tissues; however, after 30 days, C57Bl/6 and BALB/c mice showed an effective fungal clearance associated with specific production of IL-17 and IL-2. We also observed that 60% of Il17ra(-/-) mice succumbed to infection within 16 days. Conclusion: This study has established an immunocompetent model for disseminated mucormycosis and highlighted the role of IL-17 signaling in immunity against R. oryzae. (AU)

• Processo FAPESP: 13/15513-3 - Contribuição ao estudo da mucormicose: desenvolvimento de um modelo experimental murino
• Beneficiário: Amanda Ribeiro dos Santos
• Modalidade de apoio: Bolsas no Brasil - Iniciação Científica