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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Rhizopus-host interplay of disseminated mucormycosis in immunocompetent mice

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Author(s):
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dos Santos, Amanda R. [1] ; Fraga-Silva, Thais F. [2] ; Almeida, Debora de Fatima [1] ; dos Santos, Rodolfo F. [1] ; Finato, Angela C. [1] ; Amorim, Barbara C. [1] ; Andrade, I, Maria ; Soares, Cleverson T. [3] ; Lara, Vanessa S. [4] ; Almeida, Nara L. M. [4] ; de Arruda, Olavo S. [1] ; de Arruda, Maria S. P. [1] ; Venturini, James [1, 5]
Total Authors: 13
Affiliation:
[1] Univ Estadual Paulista, Fac Ciencias, UNESP, BR-17033360 Bauru, SP - Brazil
[2] Univ Estadual Paulista, Inst Biociencias, UNESP, BR-18618689 Botucatu, SP - Brazil
[3] Andrade, Maria, I, Lauro de Souza Lima Inst, BR-17034971 Bauru, SP - Brazil
[4] Univ Sao Paulo, Fac Odontol Bauru FOB, BR-17012901 Bauru, SP - Brazil
[5] Univ Fed Mato Grosso do Sul UFMS, Fac Med, BR-79070900 Campo Grande, MS - Brazil
Total Affiliations: 5
Document type: Journal article
Source: FUTURE MICROBIOLOGY; v. 15, n. 9, p. 739-752, JUN 2020.
Web of Science Citations: 0
Abstract

Aim: To investigate the immune response of disseminated Ryzopus oryzae infection in immunocompetent mice. Methods: C57Bl/6, BALB/c and Swiss wild-type mice were intravenously infected with R. oryzae; the parameters of infection and immune response were determined. Transcriptional signature of Th17 immune response and infection in Il17ra(-/-) mice were also evaluated. Results: All mouse strains showed an initial spread of R. oryzae in the target tissues; however, after 30 days, C57Bl/6 and BALB/c mice showed an effective fungal clearance associated with specific production of IL-17 and IL-2. We also observed that 60% of Il17ra(-/-) mice succumbed to infection within 16 days. Conclusion: This study has established an immunocompetent model for disseminated mucormycosis and highlighted the role of IL-17 signaling in immunity against R. oryzae. (AU)

FAPESP's process: 13/15513-3 - Contribution to the study of mucormycosis: development of an experimental murine model
Grantee:Amanda Ribeiro dos Santos
Support Opportunities: Scholarships in Brazil - Scientific Initiation