Regional cerebral blood flow at rest in obesity

Autor(es):Mostrar menos -

Silvah, Jose Henrique ^{[1, 2]} ; Marchini, Julio Sergio ^[2] ; Martires Lima, Cristiane Maria ^[2] ; Nicoletti, Carolina Ferreira ^[2] ; Santos, Leonardo Alexandre ^[1] ; Itikawa, Emerson Nobuyuki ^[1] ; Trevisan, Ana Carolina ^[1] ; Pitella, Felipe Arriva ^[1] ; Kato, Mery ^[1] ; Iucif Junior, Nelson ^[2] ; Frantz, Fabiani Gai ^[3] ; Carvalho Cunha, Selma Freire ^[2] ; Buchpiguel, Carlos Alberto ^[4] ; Wichert-Ana, Lauro ^{[4, 1, 2]}

Afiliação do(s) autor(es)

^[1] Univ Sao Paulo, Ribeirao Preto Med Sch, Dept Internal Med, Sect Nucl Med, Ribeirao Preto, SP - Brazil

^[2] Univ Sao Paulo, Ribeirao Preto Med Sch, Dept Internal Med, Div Med Nutr, Ribeirao Preto, SP - Brazil

^[3] Univ Sao Paulo, Sch Pharmaceut Sci Ribeirao Preto, Dept Clin Toxicol & Bromatol Anal, Ribeirao Preto, SP - Brazil

^[4] Univ Sao Paulo, Ctr Interdisciplinary Res Appl Neurosci, Sao Paulo - Brazil

• Tipo de documento: Artigo Científico
• Fonte: NUTRITION; v. 79-80, NOV-DEC 2020.
• Citações Web of Science: 1

Resumo

Objectives: Imaging studies have shown brain abnormalities associated with eating behavior (taste percep-tion, food intake, and food reward), neural connectivity, and cognition related to obesity. The aim of this study was to investigate whether obese individuals have changes in regional cerebral blood flow (rCBF) during fasting and rest using single-photon emission computed tomography (SPECT), and whether these differences are associated with body fat and serum levels of leptin, insulin, and glucose. Methods: For this purpose, rCBF assessed by ({[}99]mTc)-ECD-SPECT was compared between 10 obese women (30 +/- 5 y of age, body fat: 38 +/- 3 kg) and 10 lean women (30 +/- 6 y of age, body fat: 17 +/- 5 kg) using statistical parametric mapping. Pearson's coefficient and linear regression were used to search for associations among variables. Results: The obese women showed antagonic rCBF in the left frontoparietal region and greater rCBF in areas related to the default mode network and the salience network (P = 0.0001). Positive linear correlations of rCBF, body fat, and the serum levels of glucose and insulin were found, but no associations were detected using linear regression. Conclusion: Obese women showed rCBF differences in areas related to the frontoparietal neural circuit, the default mode network, and the salience network, suggesting loss of cognitive control and a higher perception of physiologic processes, such as hunger. Hyperactivation in these areas might jeopardize the recognition of changes in energy homeostasis. (C) 2020 Elsevier Inc. All rights reserved. (AU)

• Processo FAPESP: 12/21579-4 - Alterações na perfusão cerebral de obesos após administração de 75 gramas de glicose: estudo com SPECT, controlado, cego e aleatorizado
• Beneficiário: José Henrique da Silva
• Modalidade de apoio: Bolsas no Brasil - Doutorado Direto
• Processo FAPESP: 10/19821-6 - Alterações na perfusão cerebral de obesos após administração de 75 gramas de glicose. Estudo com SPECT, controlado, cego e aleatorizado
• Beneficiário: Julio Sergio Marchini
• Modalidade de apoio: Auxílio à Pesquisa - Regular
• Processo FAPESP: 12/03485-2 - Ingestão aguda de lipídeos e alteração da perfusão cerebral de pacientes obesos
• Beneficiário: Julio Sergio Marchini
• Modalidade de apoio: Auxílio à Pesquisa - Regular
• Processo FAPESP: 12/21626-2 - Ingestão aguda de lipídeos e alteração da perfusão cerebral de pacientes obesos
• Beneficiário: Cristiane Maria Mártires de Lima
• Modalidade de apoio: Bolsas no Brasil - Doutorado Direto