| Full text | |
| Author(s): Show less - |
Silvah, Jose Henrique
[1, 2]
;
Marchini, Julio Sergio
[2]
;
Martires Lima, Cristiane Maria
[2]
;
Nicoletti, Carolina Ferreira
[2]
;
Santos, Leonardo Alexandre
[1]
;
Itikawa, Emerson Nobuyuki
[1]
;
Trevisan, Ana Carolina
[1]
;
Pitella, Felipe Arriva
[1]
;
Kato, Mery
[1]
;
Iucif Junior, Nelson
[2]
;
Frantz, Fabiani Gai
[3]
;
Carvalho Cunha, Selma Freire
[2]
;
Buchpiguel, Carlos Alberto
[4]
;
Wichert-Ana, Lauro
[4, 1, 2]
Total Authors: 14
|
| Affiliation: | [1] Univ Sao Paulo, Ribeirao Preto Med Sch, Dept Internal Med, Sect Nucl Med, Ribeirao Preto, SP - Brazil
[2] Univ Sao Paulo, Ribeirao Preto Med Sch, Dept Internal Med, Div Med Nutr, Ribeirao Preto, SP - Brazil
[3] Univ Sao Paulo, Sch Pharmaceut Sci Ribeirao Preto, Dept Clin Toxicol & Bromatol Anal, Ribeirao Preto, SP - Brazil
[4] Univ Sao Paulo, Ctr Interdisciplinary Res Appl Neurosci, Sao Paulo - Brazil
Total Affiliations: 4
|
| Document type: | Journal article |
| Source: | NUTRITION; v. 79-80, NOV-DEC 2020. |
| Web of Science Citations: | 1 |
| Abstract | |
Objectives: Imaging studies have shown brain abnormalities associated with eating behavior (taste percep-tion, food intake, and food reward), neural connectivity, and cognition related to obesity. The aim of this study was to investigate whether obese individuals have changes in regional cerebral blood flow (rCBF) during fasting and rest using single-photon emission computed tomography (SPECT), and whether these differences are associated with body fat and serum levels of leptin, insulin, and glucose. Methods: For this purpose, rCBF assessed by ({[}99]mTc)-ECD-SPECT was compared between 10 obese women (30 +/- 5 y of age, body fat: 38 +/- 3 kg) and 10 lean women (30 +/- 6 y of age, body fat: 17 +/- 5 kg) using statistical parametric mapping. Pearson's coefficient and linear regression were used to search for associations among variables. Results: The obese women showed antagonic rCBF in the left frontoparietal region and greater rCBF in areas related to the default mode network and the salience network (P = 0.0001). Positive linear correlations of rCBF, body fat, and the serum levels of glucose and insulin were found, but no associations were detected using linear regression. Conclusion: Obese women showed rCBF differences in areas related to the frontoparietal neural circuit, the default mode network, and the salience network, suggesting loss of cognitive control and a higher perception of physiologic processes, such as hunger. Hyperactivation in these areas might jeopardize the recognition of changes in energy homeostasis. (C) 2020 Elsevier Inc. All rights reserved. (AU) | |
| FAPESP's process: | 12/21579-4 - Cerebral perfusion changes in obese subjects after administration of 75 grams of glucose: SPECT study, controlled, blinded and randomized |
| Grantee: | José Henrique da Silva |
| Support Opportunities: | Scholarships in Brazil - Doctorate (Direct) |
| FAPESP's process: | 10/19821-6 - Cerebral perfusion changes in obese subjects after administration of 75 grams of glucose. SPECT study, controlled, blinded and randomized |
| Grantee: | Julio Sergio Marchini |
| Support Opportunities: | Regular Research Grants |
| FAPESP's process: | 12/03485-2 - Acute intake of lipids and changes in cerebral perfusion in obese patients |
| Grantee: | Julio Sergio Marchini |
| Support Opportunities: | Regular Research Grants |
| FAPESP's process: | 12/21626-2 - Acute intake of lipids and changes in cerebral perfusion in obese patients |
| Grantee: | Cristiane Maria Mártires de Lima |
| Support Opportunities: | Scholarships in Brazil - Doctorate (Direct) |