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Acute intake of lipids and changes in cerebral perfusion in obese patients

Grant number: 12/21626-2
Support Opportunities:Scholarships in Brazil - Doctorate (Direct)
Effective date (Start): June 01, 2013
Effective date (End): May 04, 2014
Field of knowledge:Health Sciences - Medicine - Medical Clinics
Principal Investigator:Julio Sérgio Marchini
Grantee:Cristiane Maria Mártires de Lima
Host Institution: Faculdade de Medicina de Ribeirão Preto (FMRP). Universidade de São Paulo (USP). Ribeirão Preto , SP, Brazil

Abstract

Obesity and related illnesses emerge as public health problem worldwide since the mid 80's. Characterized by the accumulation of body fat, its pathophysiology cannot be solely explained by an imbalance between energy intake and consumption. There are a number of genetic, humoral, environmental and behavioral interconnected but not fully elucidated, contributing to positive energy balance and subsequent weight gain. Not much is known about the interaction between nutrient intake and physical changes of the central nervous system. Objective: to identify, through Single-Photon Emission Tomography (SPECT) after stimulation of water and lipid solution, which are the brain anatomical structures involved in lipid intake. Compare the cerebral perfusion of obese volunteers to their non-obese controls. Finally increase the knowledge about how does the acute intake of isolated macronutrients, in this case the lipid, influence the obesity pathophysiology. Methodology: a crossed case control study, where ten obese and ten non-obese volunteers will be evaluated by clinical examination, underwent to indirect calorimetry (IC), bioelectrical impedance analysis (BIA), laboratory tests (glucose, insulin, leptin and triglycerides) and SPECT after stimulation of water and lipid solution. The results will be compared with the existing literature in order to better clarify how a single macronutrient, in this case, the lipid, contributes to pathophysiology of obesity. (AU)

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Scientific publications (5)
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
SILVAH, JOSE HENRIQUE; MARTIRES DE LIMA, CRISTIANE MARIA; DEL LAMA DE UNAMUNO, MARIA DO ROSARIO; ALVES SCHETINO, MARCO ANTONIO; LEITE SCHETINO, LUANA PEREIRA D; FASSINI, PRISCILA GIACOMO; CUNHA MORAES BRANDAO, CAMILA FERNANDA COSTA E; BASILE-FILHO, ANIBAL; CARVALHO DA CUNHA, SELMA FREIRE; MARCHINI, JULIO SERGIO. Body surface infrared thermometry in patients with central venous cateter-related infections. Einstein (São Paulo), v. 13, n. 3, p. 364-369, . (12/21579-4, 12/21626-2, 12/22543-3)
LARA CASSANI, ROBERTA SOARES; FASSINI, PRISCILA GIACOMO; SILVAH, JOSE HENRIQUE; MARTIRES LIMA, CRISTIANE MARIA; MARCHINI, JULIO SERGIO. RETRACTED: Impact of weight loss diet associated with flaxseed on inflammatory markers in men with cardiovascular risk factors: a clinical study (Retracted article. See vol. 15, pg. 59, 2016). NUTRITION JOURNAL, v. 14, . (12/21579-4, 12/21626-2, 12/22543-3)
LARA CASSANI, ROBERTA SOARES; FASSINI, PRISCILA GIACOMO; SILVAH, JOSE HENRIQUE; MARTIRES LIMA, CRISTIANE MARIA; MARCHINI, JULIO SERGIO. Impact of weight loss diet associated with flaxseed on inflammatory markers in men with cardiovascular risk factors: a clinical study (Retracted article. See vol. 15, pg. 59, 2016). NUTRITION JOURNAL, v. 14, p. 8-pg., . (12/22543-3, 12/21579-4, 12/21626-2)
SILVAH, JOSE HENRIQUE; MARTIRES DE LIMA, CRISTIANE MARIA; DEL LAMA DE UNAMUNO, MARIA DO ROSARIO; ALVES SCHETINO, MARCO ANTONIO; LEITE SCHETINO, LUANA PEREIRA D; FASSINI, PRISCILA GIACOMO; CUNHA MORAES BRANDAO, CAMILA FERNANDA COSTA E; BASILE-FILHO, ANIBAL; CARVALHO DA CUNHA, SELMA FREIRE; MARCHINI, JULIO SERGIO. Body surface infrared thermometry in patients with central venous cateter-related infections. Einstein (São Paulo), v. 13, n. 3, p. 6-pg., . (12/21626-2, 12/21579-4, 12/22543-3)
SILVAH, JOSE HENRIQUE; MARCHINI, JULIO SERGIO; MARTIRES LIMA, CRISTIANE MARIA; NICOLETTI, CAROLINA FERREIRA; SANTOS, LEONARDO ALEXANDRE; ITIKAWA, EMERSON NOBUYUKI; TREVISAN, ANA CAROLINA; PITELLA, FELIPE ARRIVA; KATO, MERY; IUCIF JUNIOR, NELSON; et al. Regional cerebral blood flow at rest in obesity. NUTRITION, v. 79-80, . (12/21579-4, 10/19821-6, 12/03485-2, 12/21626-2)
Academic Publications
(References retrieved automatically from State of São Paulo Research Institutions)
LIMA, Cristiane Maria Mártires de. Acute ingestion of lipids and alteration of cerebral perfusion in obese patients. 2015. Doctoral Thesis - Universidade de São Paulo (USP). Faculdade de Medicina de Ribeirão Preto (PCARP/BC) Ribeirão Preto.

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