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ACUTE AND CHRONIC METABOLIC RESPONSES TO PHYSICAL EXERCISE IN HEALTHY, OBESE, AND DIABETIC TYPE 2 MIDDLE AGED PEOPLE USING METABOLOMICS AND LIPIDOMICS APPROACHES

Grant number: 17/11033-8
Support type:Scholarships in Brazil - Doctorate
Effective date (Start): September 01, 2017
Status:Discontinued
Field of knowledge:Health Sciences - Physical Education
Principal researcher:Claudia Regina Cavaglieri
Grantee:Renata Garbellini Duft
Home Institution: Faculdade de Educação Física (FEF). Universidade Estadual de Campinas (UNICAMP). Campinas , SP, Brazil
Associated scholarship(s):19/25817-6 - The use of machine learning to integrate lipidomics, clinical chemistry and functional parameters of normal-weight, obese and type 2 diabetic middle-aged people after 16 weeks of combined training, BE.EP.DR

Abstract

Systems Biology studies a connection between organics systems and metabolic pathways to find a comprehensive response of the organism functioning. Metabolomics is used for this to identify and quantify metabolites, among them lipids (lipidomics). These approaches possibilities to analyze alterations in metabolism caused by disturbances in metabolic homeostasis, due to physiological conditions and/or metabolic responses to exercise. It is already known that physical exercise interferes in the metabolic response, and the practice of aerobic (AT) and resistance training (RT) together, called Combined Training (CT), has been recommended for health promotion associated with obesity and diabetes in the middle-aged population. Thus, the objective of this project is analyzed acute responses of AT, RT, and CT on the metabolic and lipid profile, and chronic responses to CT using metabolomics and lipidomics in healthy, obese and type 2 diabetics, individuals. The sample will be composed of subjects in middle age (40 to 60 years), both sexes, with body mass index between 18 and 34.9 kg/m². Acute sessions of AT, RT, and CT will be realized. Chronic CT will consist of the completion of AT and RT in the same session, with the frequency of three times a week during 16 weeks. Functional, anthropometric and biochemical assessments will be performed. Metabolomics and Lipidomics will be carried out by mass spectrometry (MS). It is expected that different types of exercises promote different responses and active different metabolic pathways. The training will improve physical fitness and body composition, promoting changes in the metabolism of the volunteers, and candidates biomarkers will be found to understand better the mechanisms and metabolic pathways activated by exercise.

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