Advanced chronic kidney disease is associated with higher serum concentration of monocyte microparticles

Autor(es)

Fonseca, Francisco ^[1] ; Ballerini, Ana Paula ^[2] ; Izar, Maria Cristina ^[1] ; Kato, Juliana ^[1] ; Ferreira, Carlos Eduardo ^[3] ; Fonzar, Waleria ^[1] ; do Amaral, Jonatas ^[1] ; Rezende, Paula ^[4] ; Machado-Santelli, Glaucia ^[4] ; Franca, Carolina ^[2]

Afiliação do(s) autor(es)

^[1] Univ Fed Sao Paulo, Sao Paulo, SP - Brazil

^[2] Univ Santo Amaro, Sao Paulo, SP - Brazil

^[3] Hosp Israelita Albert Einstein, Sao Paulo, SP - Brazil

^[4] Univ Sao Paulo, Sao Paulo, SP - Brazil

• Tipo de documento: Artigo Científico
• Fonte: Life Sciences; v. 260, NOV 1 2020.
• Citações Web of Science: 1

Resumo

Advanced chronic kidney disease is associated with high rates of cardiovascular disease. Considering the crucial role of capillaries in renal function, our study aimed to evaluate microparticles related to vascular physiology examining the link between stages of chronic kidney disease with circulating endothelial (EMP), platelet (PMP) and monocytic (MMP) microparticles. Cross-sectional study with blinded endpoints included subjects of both sexes, aged 40-75 years (n = 247), with established cardiovascular disease (coronary heart disease, ischemic stroke, or peripheral artery disease). They were stratified 1:1 by the presence or absence of decreased glomerular filtration rate (GFR < 60 mL/min/1.73 m(2)) estimated by the CKD-EPI criteria, and according to the stages of CKD. Microparticles were quantified by flow-cytometry using specific antibodies to identify endothelial, platelet, and monocytic derived microparticles. Higher percentages of circulating MMP (p = 0.036), but not for EMP or PMP, were observed in subjects with reduced GFR. Circulating MMP were also related to the stages of chronic kidney disease (trend analysis across renal stages, p = 0.038). Higher percentages of circulating MMP were found in subjects with reduced GFR, and their percentages were progressively higher according to the stage of chronic renal function. (AU)

• Processo FAPESP: 13/25779-0 - Possíveis mecanismos associando a doença renal crônica com a doença cardiovascular
• Beneficiário: Carolina Nunes França
• Linha de fomento: Auxílio à Pesquisa - Regular