Prognostic and predictive value of Pleckstrin homology-like domain, family A family members in breast cancer

Autor(es):Mostrar menos -

Mangone, Flavia R. ^{[1, 2]} ; Valoyes, Maira A. V. ^{[1, 2]} ; do Nascimento, Renan G. ^{[1, 2]} ; Conceicao, Mercia P. F. ^{[1, 2]} ; Bastos, Daniel R. ^{[1, 2]} ; Pavanelli, Ana C. ^{[1, 2]} ; Soares, Ibere C. ^[3] ; de Mello, Evandro S. ^[3] ; Nonogaki, Suely ^[4] ; Osorio, Cynthia A. B. ^[4] ; Nagai, Maria A. ^{[1, 2]}

Afiliação do(s) autor(es)

^[1] Univ Sao Paulo, Dept Radiol & Oncol, Fac Med, Discipline Oncol, BR-01246903 Sao Paulo - Brazil

^[2] Canc Inst Sao Paulo, Ctr Translat Res Oncol, Lab Mol Genet, BR-01246000 Sao Paulo - Brazil

^[3] AC Camargo Canc Ctr, Dept Pathol Anat, BR-01509020 Sao Paulo - Brazil

^[4] Univ Sao Paulo, Fac Med, Hosp Clin HCFMUSP, Dept Pathol, Inst Canc, BR-01246903 Sao Paulo - Brazil

• Tipo de documento: Artigo Científico
• Fonte: BIOMARKERS IN MEDICINE; v. 14, n. 16, p. 1539-1554, NOV 2020.
• Citações Web of Science: 0

Resumo

Aim: The PHLDA (pleckstrin homology like domain, family A) gene family encodes proteins capable of inhibiting AKT (serine/threonine kinase) signaling through phosphoinositol binding competition. Results \& methodology: Using in silico analysis, we found that Luminal A and B patients' short relapse-free survival was associated with low PHLDA1 or PHLDA3 and high PHLDA2 expression. In a cohort of 393 patients with luminal breast cancer evaluated by immunohistochemistry on tissue microarrays, we found a direct association of PHLDA3 expression with hormonal therapy response (p = 0.013). Conclusion: Our findings provide new information on the role played by the PHLDA family members as prognostic markers in breast cancer, and more importantly, we provide evidence that they might also predict a response to endocrine therapy. (AU)

• Processo FAPESP: 19/05252-4 - Caracterização de novos biomarcadores preditivos de resposta a terapia endócrina e com inibidores de HER2 em câncer de mama
• Beneficiário: Maria Aparecida Nagai
• Modalidade de apoio: Auxílio à Pesquisa - Regular