Immunological Implications of Physical Inactivity among Older Adults during the COVID-19 Pandemic

Autor(es)

Damiot, Anthony ^[1] ; Pinto, Ana Jessica ^[1] ; Turner, JamesE. ^[2] ; Gualano, Bruno ^{[3, 1]}

Afiliação do(s) autor(es)

^[1] Univ Sao Paulo, Sch Phys Educ & Sport, Div Rheumatol, Appl Physiol & Nutr Res Grp, Fac Med FMUSP, Sao Paulo - Brazil

^[2] Univ Bath, Dept Hlth, Bath, Avon - England

^[3] Univ Sao Paulo, Food Res Ctr, Sao Paulo - Brazil

• Tipo de documento: Artigo Científico
• Fonte: Gerontology; v. 66, n. 5, p. 431-438, SEP 2020.
• Citações Web of Science: 3

Resumo

Social distancing has been adopted worldwide to control severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) transmission. Social isolation is likely to lead to a decline in physical activity, which could result in immune system dysfunction, thereby increasing infection susceptibility and exacerbating the pathophysiology of conditions that are common among older adults, including cardiovascular disease, cancer, and inflammatory disorders. Older adults and people living with these comorbidities are at a greater risk for complications during coronavirus disease 2019 (COVID-19). In this review, we discuss the negative impact of physical inactivity on immune function and showcase evidence that regular physical activity may be an effective strategy to counter some of the deleterious effects of social isolation. Furthermore, we briefly highlight key research questions in exercise immunology, with a focus on older adults in the context of COVID-19. Although it is worth emphasizing that there is no direct evidence that physical activity can prevent or treat COVID-19, promoting an active lifestyle is a key intervention to counteract the effects of social isolation, especially in older adults and other at-risk individuals, such as those living with chronic diseases associated with ageing and lifestyle. (c) 2020 S. Karger AG, Basel (AU)

• Processo FAPESP: 15/26937-4 - Estudos sobre (in)atividade física em pacientes com artrite reumatóide: caracterização, associações com a doença e efeitos da interrupção do tempo sedentário
• Beneficiário: Ana Jéssica Pinto
• Modalidade de apoio: Bolsas no Brasil - Doutorado Direto
• Processo FAPESP: 18/19418-9 - Efeitos agudos e crônicos da redução do tempo sedentário em pacientes com artrite reumatoide: o estudo Take a stand for health
• Beneficiário: Ana Jéssica Pinto
• Modalidade de apoio: Bolsas no Exterior - Estágio de Pesquisa - Doutorado Direto
• Processo FAPESP: 19/22160-6 - Reduzindo tempo sedentário em pacientes bariátricos: um estudo laboratorial de prova de conceito
• Beneficiário: Anthony Damiot
• Modalidade de apoio: Bolsas no Brasil - Pós-Doutorado