Is freezing of gait correlated with postural control in patients with moderate-to-severe Parkinson's disease?

Autor(es)

Coelho, Daniel Boari ^{[1, 2]} ; de Souza, Caroline Ribeiro ^[1] ; de Lima-Pardini, Andrea Cristina ^[3] ; Treza, Renata de Castro ^[2] ; Fujioka Shida, Thiago Kenzo ^[2] ; Silva-Batista, Carla ^[4] ; Teixeira, Luis Augusto ^[1]

Afiliação do(s) autor(es)

^[1] Univ Sao Paulo, Sch Phys Educ & Sport, Human Motor Syst Lab, Sao Paulo - Brazil

^[2] Fed Univ ABC, Biomed Engn, Sao Bernardo Do Campo, SP - Brazil

^[3] Queens Univ, Ctr Neurosci Studies, Lab Integrat Motor Behav, Kingston, ON - Canada

^[4] Univ Sao Paulo, Exercise Neurosci Res Grp, Sao Paulo - Brazil

• Tipo de documento: Artigo Científico
• Fonte: European Journal of Neuroscience; v. 53, n. 4 NOV 2020.
• Citações Web of Science: 0

Resumo

Freezing of gait (FoG) is one of the main reasons for movement initiation disorders and abnormal coupling of posture and gait in Parkinson's disease (PD). Patients with FoG have poor postural control when compared to patients without FoG. However, the nature of the interrelationship between FoG and domains of postural control remains unknown. The aim of this study was to estimate the association between different domains of postural control and severity of FoG in patients with moderate-to-severe PD. Thirty patients with idiopathic PD with FoG (age range 45-80 years, Hoehn \& Yahr stages 3 and 4) participated in the study. We evaluated objective (FoG-ratio during turning task) and subjective (New Freezing of Gait Questionnaire, NFoG-Q) measures of FoG severity, reactive postural adjustments in response to an external perturbation, first step anticipatory adjustment for step initiation and quiet standing stability. In the multiple regression analysis, step initiation was the strongest significant correlation of the NFoG-Q score explaining 23% of the variance of the assessment. For the objective FoG measure, mediolateral CoP amplitude in quiet standing and mediolateral CoP amplitude in step initiation explained 39% of the variance of the FoG-ratio. As main conclusions, this study identified the association between objective and subjective measure for FoG severity and postural control domains. The results support conducting step initiation training during rehabilitation of individuals with FoG. (AU)

• Processo FAPESP: 18/16909-1 - Efeitos do treinamento de força com instabilidade sobre desfechos clínicos, mecanismos espinhais e métricas cerebrais em indivíduos com bloqueio da marcha na Doença de Parkinson
• Beneficiário: Carla da Silva Batista
• Modalidade de apoio: Bolsas no Exterior - Estágio de Pesquisa - Pós-Doutorado
• Processo FAPESP: 16/13115-9 - Efeitos do treinamento de força com instabilidade sobre os desfechos clínicos, mecanismos espinhais e métricas cerebrais de indivíduos com bloqueio da marcha na doença de Parkinson
• Beneficiário: Carla da Silva Batista
• Modalidade de apoio: Bolsas no Brasil - Pós-Doutorado