Anticancer Potential of Compounds from the Brazilian Blue Amazon

Autor(es)

Wilke, V, Diego ; Jimenez, Paula C. ^[1] ; Branco, Paola C. ^[2] ; Rezende-Teixeira, Paula ^[2] ; Trindade-Silva, Amaro E. ^[3] ; Bauermeister, Anelize ^[2] ; Lopes, Norberto Peporine ^[4] ; Costa-Lotufo, V, Leticia

Afiliação do(s) autor(es)

^[1] Univ Fed Sao Paulo, Inst Mar, Dept Ciencias Mar, Santos, SP - Brazil

^[2] V, Univ Sao Paulo, Inst Ciencias Biomed, Dept Farmacol, Sao Paulo, SP - Brazil

^[3] Wilke, Diego, V, Univ Fed Ceara, Fac Med, Dept Fisiol & Farmacol, Nucleo Pesquisa & Desenvolvimento Medicamentos NP, Fortaleza, Ceara - Brazil

^[4] Univ Sao Paulo, Fac Ciencias Farmaceut Ribeirao Preto, Dept Ciencias Biomol, Nucleo Pesquisa Prod Nat & Sintet NPPNS, Ribeirao Preto, SP - Brazil

• Tipo de documento: Artigo de Revisão
• Fonte: Planta Medica; v. 87, n. 01/02 NOV 2020.
• Citações Web of Science: 0

Resumo

``Blue Amazon{''} is used to designate the Brazilian Economic Exclusive Zone, which covers an area comparable in size to that of its green counterpart. Indeed, Brazil flaunts a coastline spanning 8000 km through tropical and temperate regions and hosting part of the organisms accredited for the country's megadiversity status. Still, biodiversity may be expressed at different scales of organization; besides species inventory, genetic characteristics of living beings and metabolic expression of their genes meet some of these other layers. These metabolites produced by terrestrial creatures traditionally and lately added to by those from marine organisms are recognized for their pharmaceutical value, since over 50% of small molecule-based medicines are related to natural products. Nonetheless, Brazil gives a modest contribution to the field of pharmacology and even less when considering marine pharmacology, which still lacks comprehensive in-depth assessments toward the bioactivity of marine compounds so far. Therefore, this review examined the last 40 years of Brazilian natural products research, focusing on molecules that evidenced anticancer potential-which represents similar to 15% of marine natural products isolated from Brazilian species. This review discusses the most promising compounds isolated from sponges, cnidarians, ascidians, and microbes in terms of their molecular targets and mechanisms of action. Wrapping up, the review delivers an outlook on the challenges that stand against developing groundbreaking natural products research in Brazil and on a means of surpassing these matters. (AU)

• Processo FAPESP: 15/17177-6 - Abordagem integrada na prospecção sustentável de produtos naturais marinhos: da diversidade a substâncias anticâncer
• Beneficiário: Leticia Veras Costa Lotufo
• Modalidade de apoio: Auxílio à Pesquisa - Programa BIOTA - Temático
• Processo FAPESP: 14/50926-0 - INCT 2014: biodiversidade e produtos naturais
• Beneficiário: Vanderlan da Silva Bolzani
• Modalidade de apoio: Auxílio à Pesquisa - Programa BIOTA - Temático
• Processo FAPESP: 17/09022-8 - Proteínas Inibidoras da Apoptose (IAPs) como alvo terapêutico no melanoma: estudos com prodigininas em células resistentes ao vemurafenibe
• Beneficiário: Paola Cristina Branco
• Modalidade de apoio: Bolsas no Brasil - Pós-Doutorado
• Processo FAPESP: 17/17648-4 - Abordagem integrada na prospecção sustentável de produtos naturais marinhos: da diversidade a substâncias anticâncer
• Beneficiário: Anelize Bauermeister
• Modalidade de apoio: Bolsas no Brasil - Pós-Doutorado