Simulated gastrointestinal digestion of Brazilian acai seeds affects the content of flavan-3-ol derivatives, and their antioxidant and anti-inflammatory activities

Autor(es)

Melo, Priscilla Siqueira ^{[1, 2]} ; Massarioli, Adna Prado ^[1] ; Lazarini, Josy Goldoni ^[3] ; Soares, Jackeline Cintra ^[1] ; Franchin, Marcelo ^[3] ; Rosalen, Pedro Luiz ^[3] ; de Alencar, Severino Matias ^[1]

Afiliação do(s) autor(es)

^[1] Univ Sao Paulo, Luiz de Queiroz Coll Agr, Dept Agrifood Ind Food & Nutr, Padua Dias Ave, POB 9, BR-13418900 Piracicaba, SP - Brazil

^[2] Fed Univ Sao Carlos UFSCar, Ctr Nat Sci, Lagoa do Sino Campus, BR-18290000 Buri, SP - Brazil

^[3] Univ Estadual Campinas, Piracicaba Dent Sch, Dept Physiol Sci, 901 Limeira Ave, BR-13414903 Piracicaba, SP - Brazil

• Tipo de documento: Artigo Científico
• Fonte: HELIYON; v. 6, n. 10 OCT 2020.
• Citações Web of Science: 1

Resumo

Acai seeds (Euterpe oleracea Mart.) are the major residue generated during industrial extraction of acai fruit pulp - a popular and typical Amazon fruit rich in bioactive compounds and nutrients. In this study, we investigated the bioaccessibility of an acai seed extract using an in vitro simulated gastrointestinal digestion model. Catechin, epicatechin and procyanidins B1 and B2 were identified and quantified in the acai seed extract and monitored by HPLC-DAD through the digestion phases. Bioaccessibility of these flavan-3-ols and deactivation of reactive oxygen species decreased after the intestinal phase, except for peroxyl radical (ROO.). RAW 264.7 macrophages treated either with the digested or undigested acai seed extract showed reduced NF-kappa B activation and TNF-alpha levels, even following gastrointestinal digestion. Thus, the ROO. scavenging capacity and anti-inflammatory activity of the extract were found to be still remarkable after digestion, suggesting that acai seeds could be explored as a source of bioactive compounds for functional foods, cosmetic or pharmaceutical purposes. (AU)

• Processo FAPESP: 11/12640-9 - Identificação de antioxidantes naturais em resíduos agroindustriais: isolamento e aplicação em matriz alimentar de base lipídica
• Beneficiário: Priscilla Siqueira Melo
• Modalidade de apoio: Bolsas no Brasil - Doutorado