| Texto completo | |
| Autor(es): |
Geovanini, Glaucylara Reis
[1]
;
Vasques, Enio Rodrigues
[2]
;
Alvim, Rafael de Oliveira
[3]
;
Mill, Jose Geraldo
[4]
;
Andreao, Rodrigo Varejao
[5]
;
Vasques, Bruna Kim
[6]
;
Pereira, Alexandre Costa
[1]
;
Krieger, Jose Eduardo
[1]
Número total de Autores: 8
|
| Afiliação do(s) autor(es): | [1] Univ Sao Paulo, Med Sch, InCor Heart Inst, Lab Genet & Mol Cardiol, Sao Paulo - Brazil
[2] Univ Sao Paulo, Med Sch, Lab Med Invest LIM 37, Sao Paulo - Brazil
[3] Univ Fed Espirito Santo, Postgrad Program Publ Hlth, Vitoria, ES - Brazil
[4] Univ Fed Espirito Santo, Hlth Sci Ctr, Dept Physiol Sci, Vitoria, ES - Brazil
[5] Fed Inst Espirito Santo, Dept Elect Engn, Vitoria, ES - Brazil
[6] Univ Anhembi Morumbi, Med Sch, Sao Paulo - Brazil
Número total de Afiliações: 6
|
| Tipo de documento: | Artigo Científico |
| Fonte: | GLOBAL HEART; v. 15, n. 1 2020. |
| Citações Web of Science: | 0 |
| Resumo | |
Background: Heart rate variability (HRV) is a noninvasive method for assessing autonomic function. Age, sex, and chronic conditions influence HRV. Objectives: Our aim was to evaluate HRV measures exploring differences by age, sex, and race in a sample from a rural area. Methods: Analytical sample (n = 1,287) included participants from the 2010 to 2016 evaluation period of the Baependi Heart Study, a family-based cohort in Brazil. Participants underwent 24-hour Holter-ECG (Holter) monitoring. To derive population reference values, we restricted our analysis to a `healthy' subset (i.e. absence of medical comorbidities). A confirmatory analysis was conducted with a subgroup sample that also had HRV derived from a resting ECG 10'-protocol obtained during the same time period. Results: The `healthy' subset included 543 participants. Mean age was 40 +/- 14y, 41% were male, 74% self-referred as white and mean body-mass-index was 24 +/- 3kg/m(2). Time domain HRV measures showed significant differences by age-decade and by sex. Higher values were observed for males across almost all age-groups. Parasympathetic associated variables (rMSSD and pNN50) showed a U-shaped distribution and reversal increase above 60y. Sympathetic-parasympathetic balance variables (SDNN, SDANN) decreased linearly by age. Race differences were no significant. We compared time domain variables with complete data (Holter and resting ECG) between `healthy' versus `unhealthy' groups. Higher HRV values were shown for the `healthy' subset compared with the `unhealthy' group. Conclusion: HRV measures vary across age and sex. A U-shaped pattern and a reversal increase in parasympathetic variables may reflect an age-related autonomic dysfunction even in healthy individuals that could be used as a predictor of disease development. (AU) | |
| Processo FAPESP: | 13/17368-0 - Genômica cardiovascular: mechanismos & novas terapias - CVGen mech2ther |
| Beneficiário: | José Eduardo Krieger |
| Modalidade de apoio: | Auxílio à Pesquisa - Temático |
| Processo FAPESP: | 10/51010-8 - Estudos de associacao genomica ampla de fatores de risco associados a doencas cardiovasculares em uma amostra populacional brasileira. |
| Beneficiário: | Andréa Roseli Vançan Russo Horimoto |
| Modalidade de apoio: | Bolsas no Brasil - Pós-Doutorado |
| Processo FAPESP: | 07/58150-7 - Mapeamento genético de fatores de risco cardiovascular na população brasileira: uma abordagem de mapeamento baseada em núcleos familiares: Projeto Corações de Baependi |
| Beneficiário: | José Eduardo Krieger |
| Modalidade de apoio: | Auxílio à Pesquisa - Regular |
| Processo FAPESP: | 11/05804-5 - Caracterização fenotípica de ritmos circadianos em indivíduos com diferentes genótipos para polimorfismos nos genes relógio em diferentes regiões do Brasil: ênfase na investigação do gene PER3 e o efeito latitude |
| Beneficiário: | Mario Pedrazzoli Neto |
| Modalidade de apoio: | Auxílio à Pesquisa - Regular |