| Full text | |
| Author(s): |
Geovanini, Glaucylara Reis
[1]
;
Vasques, Enio Rodrigues
[2]
;
Alvim, Rafael de Oliveira
[3]
;
Mill, Jose Geraldo
[4]
;
Andreao, Rodrigo Varejao
[5]
;
Vasques, Bruna Kim
[6]
;
Pereira, Alexandre Costa
[1]
;
Krieger, Jose Eduardo
[1]
Total Authors: 8
|
| Affiliation: | [1] Univ Sao Paulo, Med Sch, InCor Heart Inst, Lab Genet & Mol Cardiol, Sao Paulo - Brazil
[2] Univ Sao Paulo, Med Sch, Lab Med Invest LIM 37, Sao Paulo - Brazil
[3] Univ Fed Espirito Santo, Postgrad Program Publ Hlth, Vitoria, ES - Brazil
[4] Univ Fed Espirito Santo, Hlth Sci Ctr, Dept Physiol Sci, Vitoria, ES - Brazil
[5] Fed Inst Espirito Santo, Dept Elect Engn, Vitoria, ES - Brazil
[6] Univ Anhembi Morumbi, Med Sch, Sao Paulo - Brazil
Total Affiliations: 6
|
| Document type: | Journal article |
| Source: | GLOBAL HEART; v. 15, n. 1 2020. |
| Web of Science Citations: | 0 |
| Abstract | |
Background: Heart rate variability (HRV) is a noninvasive method for assessing autonomic function. Age, sex, and chronic conditions influence HRV. Objectives: Our aim was to evaluate HRV measures exploring differences by age, sex, and race in a sample from a rural area. Methods: Analytical sample (n = 1,287) included participants from the 2010 to 2016 evaluation period of the Baependi Heart Study, a family-based cohort in Brazil. Participants underwent 24-hour Holter-ECG (Holter) monitoring. To derive population reference values, we restricted our analysis to a `healthy' subset (i.e. absence of medical comorbidities). A confirmatory analysis was conducted with a subgroup sample that also had HRV derived from a resting ECG 10'-protocol obtained during the same time period. Results: The `healthy' subset included 543 participants. Mean age was 40 +/- 14y, 41% were male, 74% self-referred as white and mean body-mass-index was 24 +/- 3kg/m(2). Time domain HRV measures showed significant differences by age-decade and by sex. Higher values were observed for males across almost all age-groups. Parasympathetic associated variables (rMSSD and pNN50) showed a U-shaped distribution and reversal increase above 60y. Sympathetic-parasympathetic balance variables (SDNN, SDANN) decreased linearly by age. Race differences were no significant. We compared time domain variables with complete data (Holter and resting ECG) between `healthy' versus `unhealthy' groups. Higher HRV values were shown for the `healthy' subset compared with the `unhealthy' group. Conclusion: HRV measures vary across age and sex. A U-shaped pattern and a reversal increase in parasympathetic variables may reflect an age-related autonomic dysfunction even in healthy individuals that could be used as a predictor of disease development. (AU) | |
| FAPESP's process: | 13/17368-0 - Cardiovascular genomics: mechanisms & novel therapeutics - CVGen mech2ther |
| Grantee: | José Eduardo Krieger |
| Support Opportunities: | Research Projects - Thematic Grants |
| FAPESP's process: | 11/05804-5 - Phenotypic characterization of circadian rhythms in different genotype individuals for clock gene polymorphisms in different regions in Brazil: an emphasis on the effect of the gene PER3 and latitude |
| Grantee: | Mario Pedrazzoli Neto |
| Support Opportunities: | Regular Research Grants |