COVID-19: Implications for People with Chagas Disease

Autor(es):Mostrar menos -

Zaidel, Ezequiel Jose ^{[1, 2]} ; Forsyth, Colin J. ^[3] ; Novick, Gabriel ^{[4, 5]} ; Marcus, Rachel ^[6] ; Ribeiro, Antonio Luiz P. ^{[7, 8]} ; Pinazo, Maria-Jesus ^[9] ; Morillo, Carlos A. ^[10] ; Echeverria, Luis Eduardo ^[11] ; Shikanai-Yasuda, Maria Aparecida ^[12] ; Buekens, Pierre ^[13] ; Perel, Pablo ^{[14, 15]} ; Meymandi, Sheba K. ^[16] ; Ralston, Kate ^[14] ; Pinto, Fausto ^{[14, 17]} ; Sosa-Estani, Sergio ^{[3, 18]}

Afiliação do(s) autor(es):Mostrar menos -

^[1] Sanatorio Guemes Hosp Privado, Buenos Aires, DF - Argentina

^[2] Univ Buenos Aires, Sch Med, Pharmacol Dept, Buenos Aires, DF - Argentina

^[3] Drugs Neglected Dis Initiat Latin Amer, Rio De Janeiro - Brazil

^[4] Tufts Univ, Friedman Sch Nutr Sci & Policy, Boston, MA 02111 - USA

^[5] Swiss Med Grp, Buenos Aires, DF - Argentina

^[6] Latin Amer Soc Chagas, Washington, DC - USA

^[7] Univ Fed Minas Gerais, Hosp Clin, Belo Horizonte, MG - Brazil

^[8] Fed Univ Minas Gerais UFMG, Sch Med, Internal Med Dept, Belo Horizonte, MG - Brazil

^[9] Univ Barcelona, ISGlobal, Hosp Clin, Barcelona - Spain

^[10] Univ Calgary, Libin Cardiovasc Inst, Calgary, AB - Canada

^[11] Cardiovasc Fdn Colombia, Dept Cardiol, Floriblanca - Colombia

^[12] Univ Sao Paulo, Sch Med, Dept Infect & Parasit Dis, Sao Paulo - Brazil

^[13] Tulane Univ, Sch Publ Hlth & Trop Med, New Orleans, LA - USA

^[14] World Heart Federat, Geneva - Switzerland

^[15] London Sch Hyg & Trop Med, Dept Noncommunicable Dis Epidemiol, London - England

^[16] Olive View UCLA Med Ctr, Ctr Excellence Chagas Dis, 14445 Olive View Dr, Sylmar, CA 91342 - USA

^[17] Univ Lisbon, Lisbon Sch Med, Dept Cardiol, CCUL, Lisbon - Portugal

^[18] CIESP CONICET, Epidemiol & Publ Hlth Res Ctr, Buenos Aires, DF - Argentina

• Tipo de documento: Artigo de Revisão
• Fonte: GLOBAL HEART; v. 15, n. 1 2020.
• Citações Web of Science: 0

Resumo

As the global COVID-19 pandemic advances, it increasingly impacts those vulnerable populations who already bear a heavy burden of neglected tropical disease. Chagas disease (CD), a neglected parasitic infection, is of particular concern because of its potential to cause cardiac, gastro-intestinal, and other complications which could increase susceptibility to COVID-19. The over one million people worldwide with chronic Chagas cardiomyopathy require special consideration because of COVID-19's potential impact on the heart, yet the pandemic also affects treatment provision to people with acute or chronic indeterminate CD. In this document, a follow-up to the WHF-IASC Roadmap on CD, we assess the implications of coinfection with SARS-CoV-2 and Trypanosoma cruzi, the etiological agent of CD. Based on the limited evidence available, we provide preliminary guidance for testing, treatment, and management of patients affected by both diseases, while highlighting emerging healthcare access challenges and future research needs. (AU)

• Processo FAPESP: 12/50273-0 - Monitoramento de pacientes imunodeprimidos com Doenças de Chagas: níveis de parasitemia e associação com o perfil, poliformismo de citonas sobrevidas e características dos isolados Trypanosoma cruzi em transplante de órgãos, uso de drogas imunossupressoras e co-infecção com o vírus da imunodeficiência humana
• Beneficiário: Maria Aparecida Shikanai Yasuda
• Modalidade de apoio: Auxílio à Pesquisa - Regular