COVID-19: Implications for People with Chagas Disease

Author(s):Show less -

Zaidel, Ezequiel Jose ^{[1, 2]} ; Forsyth, Colin J. ^[3] ; Novick, Gabriel ^{[4, 5]} ; Marcus, Rachel ^[6] ; Ribeiro, Antonio Luiz P. ^{[7, 8]} ; Pinazo, Maria-Jesus ^[9] ; Morillo, Carlos A. ^[10] ; Echeverria, Luis Eduardo ^[11] ; Shikanai-Yasuda, Maria Aparecida ^[12] ; Buekens, Pierre ^[13] ; Perel, Pablo ^{[14, 15]} ; Meymandi, Sheba K. ^[16] ; Ralston, Kate ^[14] ; Pinto, Fausto ^{[14, 17]} ; Sosa-Estani, Sergio ^{[3, 18]}

Affiliation:Show less -

^[1] Sanatorio Guemes Hosp Privado, Buenos Aires, DF - Argentina

^[2] Univ Buenos Aires, Sch Med, Pharmacol Dept, Buenos Aires, DF - Argentina

^[3] Drugs Neglected Dis Initiat Latin Amer, Rio De Janeiro - Brazil

^[4] Tufts Univ, Friedman Sch Nutr Sci & Policy, Boston, MA 02111 - USA

^[5] Swiss Med Grp, Buenos Aires, DF - Argentina

^[6] Latin Amer Soc Chagas, Washington, DC - USA

^[7] Univ Fed Minas Gerais, Hosp Clin, Belo Horizonte, MG - Brazil

^[8] Fed Univ Minas Gerais UFMG, Sch Med, Internal Med Dept, Belo Horizonte, MG - Brazil

^[9] Univ Barcelona, ISGlobal, Hosp Clin, Barcelona - Spain

^[10] Univ Calgary, Libin Cardiovasc Inst, Calgary, AB - Canada

^[11] Cardiovasc Fdn Colombia, Dept Cardiol, Floriblanca - Colombia

^[12] Univ Sao Paulo, Sch Med, Dept Infect & Parasit Dis, Sao Paulo - Brazil

^[13] Tulane Univ, Sch Publ Hlth & Trop Med, New Orleans, LA - USA

^[14] World Heart Federat, Geneva - Switzerland

^[15] London Sch Hyg & Trop Med, Dept Noncommunicable Dis Epidemiol, London - England

^[16] Olive View UCLA Med Ctr, Ctr Excellence Chagas Dis, 14445 Olive View Dr, Sylmar, CA 91342 - USA

^[17] Univ Lisbon, Lisbon Sch Med, Dept Cardiol, CCUL, Lisbon - Portugal

^[18] CIESP CONICET, Epidemiol & Publ Hlth Res Ctr, Buenos Aires, DF - Argentina

• Document type: Review article
• Source: GLOBAL HEART; v. 15, n. 1 2020.
• Web of Science Citations: 0

Abstract

As the global COVID-19 pandemic advances, it increasingly impacts those vulnerable populations who already bear a heavy burden of neglected tropical disease. Chagas disease (CD), a neglected parasitic infection, is of particular concern because of its potential to cause cardiac, gastro-intestinal, and other complications which could increase susceptibility to COVID-19. The over one million people worldwide with chronic Chagas cardiomyopathy require special consideration because of COVID-19's potential impact on the heart, yet the pandemic also affects treatment provision to people with acute or chronic indeterminate CD. In this document, a follow-up to the WHF-IASC Roadmap on CD, we assess the implications of coinfection with SARS-CoV-2 and Trypanosoma cruzi, the etiological agent of CD. Based on the limited evidence available, we provide preliminary guidance for testing, treatment, and management of patients affected by both diseases, while highlighting emerging healthcare access challenges and future research needs. (AU)

• FAPESP's process: 12/50273-0 - Monitoring of immunossupressed patients with Chagas Disease, response levels of parasitemia and associate with cytokines profile and polymorphism and patient survival and Trypanosoma cruzi isolate characteristics under organ transplant, immunosuppressive drugs
• Grantee: Maria Aparecida Shikanai Yasuda
• Support Opportunities: Regular Research Grants