Endurance Exercise Mitigates Immunometabolic Adipose Tissue Disturbances in Cancer and Obesity

Autor(es)

Rosa-Neto, Jose Cesar ^{[1, 2]} ; Silveira, Loreana Sanches ^[1]

Afiliação do(s) autor(es)

^[1] Univ Sao Paulo ICB1 USP, Inst Biomed Sci 1, Dept Syst Biol, Immunometab Res Grp, BR-05508000 Sao Paulo - Brazil

^[2] Univ Sao Paulo HC FMUSP, Clin Hosp, Fac Med, Lab Expt Surg, Dept Surg, BR-01246903 Sao Paulo - Brazil

• Tipo de documento: Artigo de Revisão
• Fonte: INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES; v. 21, n. 24 DEC 2020.
• Citações Web of Science: 1

Resumo

Adipose tissue is considered an endocrine organ whose complex biology can be explained by the diversity of cell types that compose this tissue. The immune cells found in the stromal portion of adipose tissue play an important role on the modulation of inflammation by adipocytokines secretion. The interactions between metabolic active tissues and immune cells, called immunometabolism, is an important field for discovering new pathways and approaches to treat immunometabolic diseases, such as obesity and cancer. Moreover, physical exercise is widely known as a tool for prevention and adjuvant treatment on metabolic diseases. More specifically, aerobic exercise training is able to increase the energy expenditure, reduce the nutrition overload and modify the profile of adipocytokines and myokines with paracrine and endocrine effects. Therefore, our aim in this review was to cover the effects of aerobic exercise training on the immunometabolism of adipose tissue in obesity and cancer, focusing on the exercise-related modification on adipose tissue or immune cells isolated as well as their interaction. (AU)

• Processo FAPESP: 19/09854-9 - O efeito da doxorrubicina sobre o tecido adiposo: elucidando o papel da família dos PPARs
• Beneficiário: José Cesar Rosa Neto
• Modalidade de apoio: Auxílio à Pesquisa - Regular
• Processo FAPESP: 19/09679-2 - Caracterização da subpopulação de macrófagos com deleção de PPARgamma em modelo de câncer de mama e a influência do treinamento aeróbio moderado
• Beneficiário: Loreana Sanches Silveira
• Modalidade de apoio: Bolsas no Brasil - Pós-Doutorado