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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Endurance Exercise Mitigates Immunometabolic Adipose Tissue Disturbances in Cancer and Obesity

Full text
Author(s):
Rosa-Neto, Jose Cesar [1, 2] ; Silveira, Loreana Sanches [1]
Total Authors: 2
Affiliation:
[1] Univ Sao Paulo ICB1 USP, Inst Biomed Sci 1, Dept Syst Biol, Immunometab Res Grp, BR-05508000 Sao Paulo - Brazil
[2] Univ Sao Paulo HC FMUSP, Clin Hosp, Fac Med, Lab Expt Surg, Dept Surg, BR-01246903 Sao Paulo - Brazil
Total Affiliations: 2
Document type: Review article
Source: INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES; v. 21, n. 24 DEC 2020.
Web of Science Citations: 1
Abstract

Adipose tissue is considered an endocrine organ whose complex biology can be explained by the diversity of cell types that compose this tissue. The immune cells found in the stromal portion of adipose tissue play an important role on the modulation of inflammation by adipocytokines secretion. The interactions between metabolic active tissues and immune cells, called immunometabolism, is an important field for discovering new pathways and approaches to treat immunometabolic diseases, such as obesity and cancer. Moreover, physical exercise is widely known as a tool for prevention and adjuvant treatment on metabolic diseases. More specifically, aerobic exercise training is able to increase the energy expenditure, reduce the nutrition overload and modify the profile of adipocytokines and myokines with paracrine and endocrine effects. Therefore, our aim in this review was to cover the effects of aerobic exercise training on the immunometabolism of adipose tissue in obesity and cancer, focusing on the exercise-related modification on adipose tissue or immune cells isolated as well as their interaction. (AU)

FAPESP's process: 19/09854-9 - Effect of doxorubicin upon the adipose tissue: elucidation the role of PPARs family
Grantee:José Cesar Rosa Neto
Support Opportunities: Regular Research Grants
FAPESP's process: 19/09679-2 - Characterization of PPARgamma knockout macrophages subpopulation in breast cancer model and the influence of moderate aerobic training
Grantee:Loreana Sanches Silveira
Support Opportunities: Scholarships in Brazil - Post-Doctoral