Sol-gel-derived 58S bioactive glass containing holmium aiming brachytherapy applications: A dissolution, bioactivity, and cytotoxicity study

Autor(es)

Delpino, Giulia Piagentini ^[1] ; Borges, Roger ^[1] ; Zambanini, Telma ^[1] ; Sousa Joca, Jhonny Frank ^[1] ; Gaubeur, Ivanise ^[1] ; Santos de Souza, Ana Carolina ^[1] ; Marchi, Juliana ^[1]

Afiliação do(s) autor(es)

^[1] Univ Fed ABC, Ctr Ciencias Nat & Humanas, Santo Andre, SP - Brazil

• Tipo de documento: Artigo Científico
• Fonte: Materials Science & Engineering C-Materials for Biological Applications; v. 119, FEB 2021.
• Citações Web of Science: 0

Resumo

Bioactive glasses containing rare earth elements have been proposed as promising candidates for applications in brachytherapy of bone cancer. However, their safety relies on a proper dissolution to avoid radioactive materials in the human body, and desirable bioactive properties to regenerate the bone defect caused by the tumor. In this work, we proposed a new series of sol-gel-derived bioactive glasses containing holmium oxide, based on the system (100-x)(58SiO(2)-33CaO-9P(2)O(5))-xHo(2)O(3) (x = 1.25, 2.5 and 5 wt%). The glasses were characterized regarding their dissolution behavior, bioactivity, and cytotoxicity with pre-osteoblastic cells. Also, in the dissolution experiments, the Arrhenius and Eyring equations were used to obtain some thermodynamic properties of glass dissolution. The results evidenced that the addition of holmium ions in the glass structure decreased the energy barrier of hydrolysis reactions, which favors glass dissolution in an early-stage. However, in the long-term, the strength of Si-O-Ho bonds may be the cause of more stable dissolution. Besides, glasses containing holmium were as bioactive as the 58S bioactive glasses, a highly bioactive composition. Cytotoxicity results showed that all glasses were not cytotoxic, and the composition containing 5 wt.% of Ho2O3 enhanced cell viability. Finally, these results suggest that these glasses are suitable materials for brachytherapy applications due to their proper dissolution behavior, high bioactivity, and high cell viability. (AU)

• Processo FAPESP: 16/23878-0 - Consolidação e inovação da linha de pesquisa: desenvolvimento de métodos analíticos combinados a microextração em fase líquida
• Beneficiário: Ivanise Gaubeur
• Modalidade de apoio: Auxílio à Pesquisa - Regular
• Processo FAPESP: 17/18753-6 - Análise de dissolução e caracterização biológica in vitro de biovidros de sistema SiO2-CaO-P2O5 dopados com hólmio
• Beneficiário: Giulia Piagentini Delpino
• Modalidade de apoio: Bolsas no Brasil - Iniciação Científica