Sol-gel-derived 58S bioactive glass containing holmium aiming brachytherapy applications: A dissolution, bioactivity, and cytotoxicity study

Author(s)

Delpino, Giulia Piagentini ^[1] ; Borges, Roger ^[1] ; Zambanini, Telma ^[1] ; Sousa Joca, Jhonny Frank ^[1] ; Gaubeur, Ivanise ^[1] ; Santos de Souza, Ana Carolina ^[1] ; Marchi, Juliana ^[1]

Affiliation

^[1] Univ Fed ABC, Ctr Ciencias Nat & Humanas, Santo Andre, SP - Brazil

• Document type: Journal article
• Source: Materials Science & Engineering C-Materials for Biological Applications; v. 119, FEB 2021.
• Web of Science Citations: 0

Abstract

Bioactive glasses containing rare earth elements have been proposed as promising candidates for applications in brachytherapy of bone cancer. However, their safety relies on a proper dissolution to avoid radioactive materials in the human body, and desirable bioactive properties to regenerate the bone defect caused by the tumor. In this work, we proposed a new series of sol-gel-derived bioactive glasses containing holmium oxide, based on the system (100-x)(58SiO(2)-33CaO-9P(2)O(5))-xHo(2)O(3) (x = 1.25, 2.5 and 5 wt%). The glasses were characterized regarding their dissolution behavior, bioactivity, and cytotoxicity with pre-osteoblastic cells. Also, in the dissolution experiments, the Arrhenius and Eyring equations were used to obtain some thermodynamic properties of glass dissolution. The results evidenced that the addition of holmium ions in the glass structure decreased the energy barrier of hydrolysis reactions, which favors glass dissolution in an early-stage. However, in the long-term, the strength of Si-O-Ho bonds may be the cause of more stable dissolution. Besides, glasses containing holmium were as bioactive as the 58S bioactive glasses, a highly bioactive composition. Cytotoxicity results showed that all glasses were not cytotoxic, and the composition containing 5 wt.% of Ho2O3 enhanced cell viability. Finally, these results suggest that these glasses are suitable materials for brachytherapy applications due to their proper dissolution behavior, high bioactivity, and high cell viability. (AU)

• FAPESP's process: 16/23878-0 - Consolidation and innovation in the research line: analytical methods development combined to liquid phase microextraction
• Grantee: Ivanise Gaubeur
• Support Opportunities: Regular Research Grants
• FAPESP's process: 17/18753-6 - Dissolution analysis and in vitro biological characterization of SiO2-CaO-P2O5 system bioglasses doped with holmium
• Grantee: Giulia Piagentini Delpino
• Support Opportunities: Scholarships in Brazil - Scientific Initiation