Development and characterization of wollastonite cement for bone tissue engineering

• Grant number: 20/12507-6
• Support Opportunities: Regular Research Grants
• Start date: July 01, 2021
• End date: June 30, 2023
• Field of knowledge: Engineering - Materials and Metallurgical Engineering
• Principal Investigator: Gilmar Patrocínio Thim
• Grantee: Gilmar Patrocínio Thim
• Host Institution: Divisão de Ciências Fundamentais (IEF). Instituto Tecnológico de Aeronáutica (ITA). Ministério da Defesa (Brasil). São José dos Campos , SP, Brazil
• Associated researchers: Dayane Batista Tada ; Letícia Terumi Kito ; Liana Alvares Rodrigues ; Raíssa Monteiro Pereira ; Thaís Larissa do Amaral Montanheiro ; Tiago Moreira Bastos Campos ; Vanessa Modelski Schatkoski

Abstract

As human life expectancy increases and degenerative bone diseases become more common, especially in the elderly, the need to develop synthetic biomaterials for bone repair and regeneration is becoming increasingly important. In this context, wollastonite-based cements (CaSiO3) have been shown to be a viable biomaterial alternative due to characteristics such as biocompatibility, bioactivity and osteoconductivity. CaSiO3-based cements are formed from a reaction between a solution containing phosphate ions (HPO4-) and CaSiO3 powder, resulting in a paste that spontaneously hardens at room temperature, precipitating hydroxyapatite and a glassy silicate. However, the mechanical properties of these materials are still not satisfactory, which is often a limiting factor for the use of wollastonite cements in several applications. In order to improve the mechanical properties of cements, studies have been directed to the application of various materials as reinforcing agents through the formation of a composite material, such as carbon fibers and glass fibers. However, many of these fibers have been shown to be toxic to cells, hindering their clinical application. One material capable of overcome such restrictions is cellulose nanocrystals (CNCs). CNCs are the crystalline part of cellulosic materials, which can be extracted from trees and a variety of plants. As a reinforcement material, CNCs have some advantages, including biodegradability, biocompatibility, high abundance, low cost and excellent mechanical properties. Therefore, the main objective of this project is to incorporate CNCs in wollastonite cement in order to promote a change in the final mechanical properties of this cement, without loss of biocompatibility and bioactivity aiming at applications in bone tissue repairs in a more comprehensive way, reducing the risk of fracture. Thus, this work presents an innovative study regarding the production of a cement based on wollastonite with good biocompatibility and adequate mechanical properties through the insertion of a small amount of CNCs in the cement. (AU)

Scientific publications

(8)

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

DO AMARAL MONTANHEIRO, THAIS LARISSA; SCHATKOSKI, VANESSA MODELSKI; CANUTO DE MENEZES, BEATRIZ ROSSI; PEREIRA, RAISSA MONTEIRO; RIBAS, RENATA GUIMARAES; MARTINEZ DE FREITAS, AMANDA DE SOUSA; LEMES, ANA PAULA; VAZ FERNANDES, MARIA HELENA FIGUEIRA; THIM, GILMAR PATROCINIO. Recent progress on polymer scaffolds production: Methods, main results, advantages and disadvantages. EXPRESS POLYMER LETTERS, v. 16, n. 2, p. 197-219, FEB 2022. (17/02846-5, 17/27079-7, 17/24873-4, 18/12035-7, 20/12507-6)

ROSSI, NATALIA RIVOLI; CANUTO DE MENEZES, BEATRIZ ROSSI; SAMPAIO, ALINE DA GRACA; DA SILVA, DIEGO MORAIS; KOGA-ITO, CRISTIANE YUMI; THIM, GILMAR PATROCINIO; DE ARRUDA PAES-JUNIOR, TARCISIO JOSE. Silver-Coated Silica Nanoparticles Modified with MPS: Potential Antimicrobial Biomaterials Applied in Glaze and Soft Reliner. POLYMERS, v. 14, n. 20, p. 19-pg., 2022-10-01. (20/12507-6)

DAMASCENO, BARBARA S.; HORTA, ISABELA M.; DE OLIVEIRA, REGIANE S.; PEREIRA, RAISSA M.; SCHATKOSKI, VANESSA M.; BACHER, GERD; MASSI, MARCOS; THIM, GILMAR P.; DE J PEREIRA, ANDRE L.; DA SILVA SOBRINHO, ARGEMIRO S.; et al. Recent improvements on surface acoustic wave sensors based on graphenic nanomaterials. MATERIALS SCIENCE IN SEMICONDUCTOR PROCESSING, v. 167, p. 20-pg., 2023-08-27. (15/06241-5, 21/05217-4, 20/12507-6)

RODRIGUES, KARLA FAQUINE; DE MORAES, NICOLAS PERCIANI; DOS SANTOS, ALAN SILVA; DO AMARAL MONTANHEIRO, THAIS LARISSA; BASTOS CAMPOS, TIAGO MOREIRA; THIM, GILMAR PATROCINIO; RODRIGUES, LIANA ALVARES; BRUNELLI, DEBORAH DIBBERN. Enhanced 4-chlorophenol Degradation under Visible and Solar Radiation through TiO2/g-C3N4 Z-Scheme Heterojunction. BIOINTERFACE RESEARCH IN APPLIED CHEMISTRY, v. 13, n. 3, p. 18-pg., 2023-06-15. (17/24873-4, 20/12874-9, 18/16360-0, 20/12507-6, 18/10492-1)

DOS SANTOS, VERONICA RIBEIRO; CAMPOS, TIAGO MOREIRA BASTOS; THIM, GILMAR PATROCINIO; BORGES, ALEXANDRE LUIZ SOUTO; TRICHES, ELIANDRA DE SOUSA. Glycol thermal synthesis of the 45B5 bioactive borate glass: Structural, physical, and apatite mineralization in vitro. CERAMICS INTERNATIONAL, v. 49, n. 7, p. 13-pg., 2023-02-21. (20/12507-6, 19/19594-4, 20/12874-9, 19/10877-3)

GUIMARAES, CAROLINA CURCIO LOTT; DE SOUZA, JOYCE RODRIGUES; CAMPOS, TIAGO MOREIRA BASTOS; MARQUES, THAYS OLIVEIRA; KITO, LETICIA TERUMI; KUKULKA, ELISA CAMARGO; DE VASCONCELLOS, LUANA MAROTTA REIS; BORGES, ALEXANDRE LUIZ SOUTO; THIM, GILMAR PATROCINIO. Chlorinated-based bioceramics incorporated in polycaprolactone membranes. JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART B-APPLIED BIOMATERIALS, v. N/A, p. 11-pg., 2023-08-17. (20/12874-9, 20/12507-6)

KUKULKA, ELISA CAMARGO; DE SOUZA, JOYCE RODRIGUES; RIBEIRO DE ARAUJO, JULIANI CAROLINI; REIS DE VASCONCELLOS, LUANA MAROTTA; BASTOS CAMPOS, TIAGO MOREIRA; THIM, GILMAR PATRICINIO; SOUTO BORGES, ALEXANDRE LUIZ. Polycaprolactone/chlorinated bioglass scaffolds doped with Mg and Li ions: Morphological, physicochemical, and biological analysis. JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART B-APPLIED BIOMATERIALS, v. 111, n. 1, p. 11-pg., 2022-07-19. (20/12874-9, 20/12507-6)

FERNANDES, MARINA SANTOS; KUKULKA, ELISA CAMARGO; DE SOUZA, JOYCE RODRIGUES; SOUTO BORGES, ALEXANDRE LUIZ; BASTOS CAMPOS, TIAGO MOREIRA; THIM, GILMAR PATROCINIO; REIS DE VASCONCELLOS, LUANA MAROTTA. Development and characterization of PCL membranes incorporated with Zn-doped bioactive glass produced by electrospinning for osteogenesis evaluation. JOURNAL OF POLYMER RESEARCH, v. 29, n. 9, p. 17-pg., 2022-09-01. (20/12874-9, 20/12507-6, 19/25744-9)