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Reinforcement of a wollastonite cement (CaSiO3) by carbon nanotubes for biomedical or dental applications

Grant number: 17/27079-7
Support type:Scholarships in Brazil - Doctorate
Effective date (Start): December 01, 2018
Status:Discontinued
Field of knowledge:Engineering - Materials and Metallurgical Engineering - Nonmetallic Materials
Principal Investigator:Gilmar Patrocínio Thim
Grantee:Renata Guimarães Ribas
Home Institution: Divisão de Engenharia Mecânica (IEM). Instituto Tecnológico de Aeronáutica (ITA). Ministério da Defesa (Brasil). São José dos Campos , SP, Brazil
Associated scholarship(s):20/02379-0 - Cellular differentiation potential of mesenchymal stem cells on wollastonite cement scaffolds in a biomechanical perfusion bioreactor, BE.EP.DR

Abstract

In the last decades, the life expectancy of the population has been increasing and with it some age-related evils such as Osteoporosis and Osteoarthritis. In orthopedic surgeries, for example, there may be a need to fill defects with materials compatible with the patient's bone system. Thus, there is a need to develop materials to repair and interact with biological systems, also known with biomaterials. Calcium silicate-based bioceramics, such as wollastonite (CaSiO3), have great potential because of their similarity to the bone structure of the human body, low toxicity, bioactivity, and biocompatibility. The main feature, however, is the formation of a layer of hydroxyapatite on its surface. Thus, the use of wollastonite to make cements for the dental and orthopedic application is quite feasible and has great potential, since it presents biocompatibility similar to that of the bioglass and superior to the phosphate based cements. Several methods can be used to produce wollastonite, such as precipitation and reaction in the solid state. The sol-gel method presents an advantage in relation to the others to produce silicates with high homogeneity. This characteristic is indispensable for biological applications.However, the low mechanical resistance to fracture is often a limitation for the use of wollastonite in different applications. An interesting approach is to reinforce the cement with carbon nanotubes. Thus, in addition to biocompatibility, this cement would have mechanical resistance comparable to phosphate based cements. Previous studies on polymer matrices and on certain bioceramics have already proved the efficiency of nanotubes in increasing the final mechanical properties of these materials. Although recent studies have shown this potential, few studies have dealt with nanotube reinforced wollastonite, and still less has a comprehensive study on the characterization of the mechanical properties of these reinforced cements. In this way, this work would present an unpublished study for the formation of a wollastonite based cement that would have a good biocompatibility while presenting adequate mechanical properties. The main objective of this work is to incorporate the functionalized carbon nanotubes in a wollastonite based cement, in order to modify the final mechanical properties of this cement, without losing the biocompatibility. In addition, it is intended to make a more extensive study regarding the characterization of the mechanical properties of these cements reinforced with carbon nanotubes. Therfore, a wollastonite with better mechanical properties can be applied in dental and orthopedic procedures more comprehensively, reducing the risk of fracture. In addition, the study of wollastonite (CaSiO3) may help to better understand the kinetic and chemical mechanisms of other calcium silicates. (AU)

Scientific publications (7)
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
DE MENEZES, BEATRIZ ROSSI CANUTO; RODRIGUES, KARLA FAQUINE; SCHATKOSKI, VANESSA MODELSKI; PEREIRA, RAISSA MONTEIRO; RIBAS, RENATA GUIMARAES; MONTANHEIRO, THAIS LARISSA DO AMARAL; THIM, GILMAR PATROCINIO. Current advances in drug delivery of nanoparticles for respiratory disease treatment. JOURNAL OF MATERIALS CHEMISTRY B, v. 9, n. 7, p. 1745-1761, FEB 21 2021. Web of Science Citations: 0.
SCHATKOSKI, VANESSA MODELSKI; MONTANHEIRO, THAIS LARISSA DO AMARAL; CANUTO DE MENEZES, BEATRIZ ROSSI; PEREIRA, RAISSA MONTEIRO; RODRIGUES, KARLA FAQUINE; RIBAS, RENATA GUIMARAES; DA SILVA, DIEGO MORAIS; THIM, GILMAR PATROCINIO. Current advances concerning the most cited metal ions doped bioceramics and silicate-based bioactive glasses for bone tissue engineering. CERAMICS INTERNATIONAL, v. 47, n. 3, p. 2999-3012, FEB 1 2021. Web of Science Citations: 0.
SPIRANDELI, BRUNO ROBERTO; BASTOS CAMPOS, TIAGO MOREIRA; RIBAS, RENATA GUIMARAES; THIM, GILMAR PATROCINIO; TRICHES, ELIANDRA DE SOUSA. Evaluation of colloidal and polymeric routes in sol-gel synthesis of a bioactive glass-ceramic derived from 45S5 bioglass. CERAMICS INTERNATIONAL, v. 46, n. 12, p. 20264-20271, AUG 15 2020. Web of Science Citations: 0.
MONTANHEIRO, THAIS LARISSA DO AMARAL; RIBAS, RENATA GUIMARAES; MONTAGNA, LARISSA STIEVEN; DE MENEZES, BEATRIZ ROSSI CANUTO; SCHATKOSKI, VANESSA MODELSKI; RODRIGUES, KARLA FAQUINE; THIM, GILMAR PATROCINIO. A brief review concerning the latest advances in the influence of nanoparticle reinforcement into polymeric-matrix biomaterials. JOURNAL OF BIOMATERIALS SCIENCE-POLYMER EDITION, v. 31, n. 14 JUN 2020. Web of Science Citations: 0.
RIBAS, RENATA GUIMARAES; BASTOS CAMPOS, TIAGO MOREIRA; SCHATKOSKI, VANESSA MODELSKI; CANUTO DE MENEZES, BEATRIZ ROSSI; DO AMARAL MONTANHEIRO, THAIS LARISSA; THIM, GILMAR PATROCINIO. alpha-wollastonite crystallization at low temperature. CERAMICS INTERNATIONAL, v. 46, n. 5, p. 6575-6580, APR 1 2020. Web of Science Citations: 0.
RIBAS, RENATA GUIMARDES; SCHATKOSKI, VANESSA MODELSKI; DO AMARAL MONTANHEIRO, THAIS LARISSA; CANUTO DE MENEZES, BEATRIZ ROSSI; STEGEMANN, CRISTIANE; GONSALVES LEITE, DOUGLAS MARCEL; THIM, GILMAR PATROCINIO. Current advances in bone tissue engineering concerning ceramic and bioglass scaffolds: A review. CERAMICS INTERNATIONAL, v. 45, n. 17, A, p. 21051-21061, DEC 1 2019. Web of Science Citations: 0.
DO AMARAL MONTANHEIRO, THAIS LARISSA; CANUTO DE MENEZES, BEATRIZ ROSSI; RIBAS, RENATA GUIMARAES; MONTAGNA, LARISSA STIEVEN; BASTOS CAMPOS, TIAGO MOREIRA; SCHATKOSKI, VANESSA MODELSKI; NIETO RIGHETTI, VICTOR AUGUSTO; PASSADOR, FABIO ROBERTO; THIM, GILMAR PATROCINIO. Covalently gamma-aminobutyric acid-functionalized carbon nanotubes: improved compatibility with PHBV matrix. SN APPLIED SCIENCES, v. 1, n. 10 OCT 2019. Web of Science Citations: 0.

Please report errors in scientific publications list by writing to: cdi@fapesp.br.