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Cellular differentiation potential of mesenchymal stem cells on wollastonite cement scaffolds in a biomechanical perfusion bioreactor

Grant number: 20/02379-0
Support type:Scholarships abroad - Research Internship - Doctorate
Effective date (Start): November 14, 2020
Effective date (End): November 13, 2021
Field of knowledge:Interdisciplinary Subjects
Principal researcher:Gilmar Patrocínio Thim
Grantee:Renata Guimarães Ribas
Supervisor abroad: Peter Ernst Michael Muller
Home Institution: Divisão de Engenharia Mecânica (IEM). Instituto Tecnológico de Aeronáutica (ITA). Ministério da Defesa (Brasil). São José dos Campos , SP, Brazil
Research place: Ludwig Maximilian University of Munich (LMU Munich), Germany  
Associated to the scholarship:17/27079-7 - Reinforcement of a wollastonite cement (CaSiO3) by carbon nanotubes for biomedical or dental applications, BP.DR

Abstract

In the last decades, diseases such as osteoporosis and osteoarthritis are becoming a common occurrence and the necessity of new technologies for bone regeneration has been growing. The most usual and known as the gold standard for this treatment is autograft. The problem associated with this technique is potential infections and the poverty of availability for certain applications. Bioceramics, as wollastonite, has great potential for this type of treatment and can be considered a good option. The cement of wollastonite (CaSiO3) promotes cellular adhesion and increases bone regeneration capacity. This cement forms a hydroxyapatite layer that has good interaction with the bone tissue. Besides that, it liberates ions that promote osteoconduction and osteoinduction. Unfortunately, the path to developing a proven biomaterial that actually will work, as it should in vivo and subsequently the results be translated clinically is both costly and time consuming. This occurs because of many variables of growth factors that should be considered as nuclear proteins and hormones. As a matter of fact, the most modern biological in vitro tests are done nowadays in bioreactors because they can be made to replicate in vivo systems. In this regard, it is extremely important to simulate the organic system as close to the real model, that is, the human body. In this way, wollastonite cement can be better optimized making it safer for consideration in clinical applications.