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(Referência obtida automaticamente do Web of Science, por meio da informação sobre o financiamento pela FAPESP e o número do processo correspondente, incluída na publicação pelos autores.)

Safety and Photoprotective Efficacy of a Sunscreen System Based on Grape Pomace (Vitis vinifera L.) Phenolics from Winemaking

Texto completo
Autor(es):
Hubner, Alexandra A. [1] ; Sarruf, Fernanda D. [2] ; Oliveira, Camila A. [1] ; Neto, V, Alberto ; Fischer, Dominique C. H. [3] ; Kato, Edna T. M. [3] ; Lourenco, Felipe R. [3] ; Baby, Andre Rolim [3] ; Bacchi, Elfriede M. [3]
Número total de Autores: 9
Afiliação do(s) autor(es):
[1] Univ Sao Paulo, Sch Pharmaceut Sci, BR-05508000 Sao Paulo - Brazil
[2] IPclin Inst Integrated Clin Res, BR-13200000 Jundiai - Brazil
[3] Neto, Alberto, V, Univ Sao Paulo, Sch Pharmaceut Sci, BR-05508000 Sao Paulo - Brazil
Número total de Afiliações: 3
Tipo de documento: Artigo Científico
Fonte: PHARMACEUTICS; v. 12, n. 12 DEC 2020.
Citações Web of Science: 0
Resumo

In winemaking, a large amount of grape pomace is produced that is rich in polyphenolics and highly beneficial for human health, as phenols are useful for skin ultraviolet (UV) protection. In this investigation, we evaluated the safety and clinical efficacy of a sunscreen system containing a grape pomace extract from Vitis vinifera L. as a bioactive ingredient. The recovery of phenolics in the waste was performed by percolation. Nine emulsions were developed using a factorial design and two were evaluated clinically: Formulation E, containing only UV filters (butylmethoxydibenzoyl methane, ethylhexyl methoxycinnamate and ethylhexyl dimethyl PABA), and F, with the extract at 10.0% w/w + UV filters. The antioxidant activity was determined by the DPPH assay and the in vitro efficacy was established by sun protection factor (SPF) measurements (Labsphere UV-2000S). Clinical tests were performed to determine safety (human repeated insult patch test) and to confirm efficacy (photoprotective effectiveness in participants). The results showed a synergistic effect between the sunscreen system and the extract on UVB protection and antioxidant activity. Both samples were considered safe. Formulation F was 20.59% more efficient in protecting skin against UVB radiation, taking approximately 21% more time to induce erythema compared to the extract-free sample. (AU)

Processo FAPESP: 08/57800-0 - Fotoprotetores de amplo espectro: desenvolvimento conceitual e prático de fotoprotetores bioativos
Beneficiário:André Rolim Baby
Modalidade de apoio: Auxílio à Pesquisa - Regular
Processo FAPESP: 16/24360-4 - Eficácia antilipoperoxidativa e anti-inflamatória de protetores solares multifuncionais contendo ácido ferúlico
Beneficiário:André Rolim Baby
Modalidade de apoio: Auxílio à Pesquisa - Regular