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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Safety and Photoprotective Efficacy of a Sunscreen System Based on Grape Pomace (Vitis vinifera L.) Phenolics from Winemaking

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Author(s):
Hubner, Alexandra A. [1] ; Sarruf, Fernanda D. [2] ; Oliveira, Camila A. [1] ; Neto, V, Alberto ; Fischer, Dominique C. H. [3] ; Kato, Edna T. M. [3] ; Lourenco, Felipe R. [3] ; Baby, Andre Rolim [3] ; Bacchi, Elfriede M. [3]
Total Authors: 9
Affiliation:
[1] Univ Sao Paulo, Sch Pharmaceut Sci, BR-05508000 Sao Paulo - Brazil
[2] IPclin Inst Integrated Clin Res, BR-13200000 Jundiai - Brazil
[3] Neto, Alberto, V, Univ Sao Paulo, Sch Pharmaceut Sci, BR-05508000 Sao Paulo - Brazil
Total Affiliations: 3
Document type: Journal article
Source: PHARMACEUTICS; v. 12, n. 12 DEC 2020.
Web of Science Citations: 0
Abstract

In winemaking, a large amount of grape pomace is produced that is rich in polyphenolics and highly beneficial for human health, as phenols are useful for skin ultraviolet (UV) protection. In this investigation, we evaluated the safety and clinical efficacy of a sunscreen system containing a grape pomace extract from Vitis vinifera L. as a bioactive ingredient. The recovery of phenolics in the waste was performed by percolation. Nine emulsions were developed using a factorial design and two were evaluated clinically: Formulation E, containing only UV filters (butylmethoxydibenzoyl methane, ethylhexyl methoxycinnamate and ethylhexyl dimethyl PABA), and F, with the extract at 10.0% w/w + UV filters. The antioxidant activity was determined by the DPPH assay and the in vitro efficacy was established by sun protection factor (SPF) measurements (Labsphere UV-2000S). Clinical tests were performed to determine safety (human repeated insult patch test) and to confirm efficacy (photoprotective effectiveness in participants). The results showed a synergistic effect between the sunscreen system and the extract on UVB protection and antioxidant activity. Both samples were considered safe. Formulation F was 20.59% more efficient in protecting skin against UVB radiation, taking approximately 21% more time to induce erythema compared to the extract-free sample. (AU)

FAPESP's process: 08/57800-0 - Broad-spectrum sunscreens: conceptual and practical development of bioactive sunscreens
Grantee:André Rolim Baby
Support Opportunities: Regular Research Grants
FAPESP's process: 16/24360-4 - Antilipoperoxidative and anti-inflammatory effects of multifunctional sunscreens containing ferulic acid
Grantee:André Rolim Baby
Support Opportunities: Regular Research Grants