ICP-MS and trace element analysis as tools for better understanding medical conditions

Autor(es)

Amais, Renata S. ^[1] ; Donati, George L. ^[2] ; Zezzi Arruda, Marco A. ^[1]

Afiliação do(s) autor(es)

^[1] Univ Estadual Campinas, Inst Chem, Spectrometry Sample Preparat & Mech Grp GEPAM, POB 6154, BR-13083970 Campinas, SP - Brazil

^[2] Wake Forest Univ, Dept Chem, Salem Hall, Box 7486, Winston Salem, NC 27109 - USA

• Tipo de documento: Artigo de Revisão
• Fonte: TRAC-TRENDS IN ANALYTICAL CHEMISTRY; v. 133, DEC 2020.
• Citações Web of Science: 0

Resumo

Element constitution and distribution in tissues and body fluids have increasingly become key pieces of information in life sciences and medicine, and trace elements may be successfully used as disease biomarkers. Here, we review the most recent advances in inductively coupled plasma mass spectrometry (ICP-MS) and the related state-of-the-art instrumentation and methods (e.g. single-particle and single- cell determination capabilities) used to expand the application of trace element information to the study of diseases. Advanced statistical tools and machine learning used for evaluating, diagnosing, and treating different diseases has highlighted the importance of trace elements in clinical research. In this manuscript, we review recently published studies involving trace element analysis and machine learning applied to better understanding clinical conditions and pathologies, and discuss some perspectives for this field. (C) 2020 Elsevier B.V. All rights reserved. (AU)

• Processo FAPESP: 18/23478-7 - Avaliação qualitativa da distribuição elementar e bioimageamento através da ablação a laser e espectrometria de massa com plasma acoplado indutivamente (LA-ICP-MS) em anéis de árvores e espeleotemas
• Beneficiário: Renata Stábile Amais
• Modalidade de apoio: Bolsas no Brasil - Pós-Doutorado
• Processo FAPESP: 18/25207-0 - Nanometalômica aplicada ao cultivo da soja para estudar os efeitos das nanopartículas relacionadas a metal
• Beneficiário: Marco Aurelio Zezzi Arruda
• Modalidade de apoio: Auxílio à Pesquisa - Temático
• Processo FAPESP: 14/50867-3 - INCT 2014: Instituto Nacional de Ciência e Tecnologia de Bioanalítica
• Beneficiário: Marco Aurelio Zezzi Arruda
• Modalidade de apoio: Auxílio à Pesquisa - Temático