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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

ICP-MS and trace element analysis as tools for better understanding medical conditions

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Author(s):
Amais, Renata S. [1] ; Donati, George L. [2] ; Zezzi Arruda, Marco A. [1]
Total Authors: 3
Affiliation:
[1] Univ Estadual Campinas, Inst Chem, Spectrometry Sample Preparat & Mech Grp GEPAM, POB 6154, BR-13083970 Campinas, SP - Brazil
[2] Wake Forest Univ, Dept Chem, Salem Hall, Box 7486, Winston Salem, NC 27109 - USA
Total Affiliations: 2
Document type: Review article
Source: TRAC-TRENDS IN ANALYTICAL CHEMISTRY; v. 133, DEC 2020.
Web of Science Citations: 0
Abstract

Element constitution and distribution in tissues and body fluids have increasingly become key pieces of information in life sciences and medicine, and trace elements may be successfully used as disease biomarkers. Here, we review the most recent advances in inductively coupled plasma mass spectrometry (ICP-MS) and the related state-of-the-art instrumentation and methods (e.g. single-particle and single- cell determination capabilities) used to expand the application of trace element information to the study of diseases. Advanced statistical tools and machine learning used for evaluating, diagnosing, and treating different diseases has highlighted the importance of trace elements in clinical research. In this manuscript, we review recently published studies involving trace element analysis and machine learning applied to better understanding clinical conditions and pathologies, and discuss some perspectives for this field. (C) 2020 Elsevier B.V. All rights reserved. (AU)

FAPESP's process: 18/23478-7 - Qualitative elemental distribution evaluation and elemental bioimaging through laser ablation inductively coupled plasma mass spectrometry (LA-ICP-MS) to tree rings and speleothems
Grantee:Renata Stábile Amais
Support Opportunities: Scholarships in Brazil - Post-Doctoral
FAPESP's process: 18/25207-0 - Nanometallomics applied to soybean cultivation for studying the effects of metal-related nanoparticles
Grantee:Marco Aurelio Zezzi Arruda
Support Opportunities: Research Projects - Thematic Grants
FAPESP's process: 14/50867-3 - INCT 2014: National Institute of Science and Technology in Bioanalysis
Grantee:Marco Aurelio Zezzi Arruda
Support Opportunities: Research Projects - Thematic Grants