Nanometallomics applied to soybean cultivation for studying the effects of metal-related nanoparticles

• Grant number: 18/25207-0
• Support Opportunities: Research Projects - Thematic Grants
• Start date: October 01, 2019
• End date: September 30, 2025
• Field of knowledge: Physical Sciences and Mathematics - Chemistry - Analytical Chemistry
• Principal Investigator: Marco Aurelio Zezzi Arruda
• Grantee: Marco Aurelio Zezzi Arruda
• Host Institution: Instituto de Química (IQ). Universidade Estadual de Campinas (UNICAMP). Campinas , SP, Brazil
• Pesquisadores principais: Ricardo Antunes de Azevedo
• Associated researchers: Claudio Francisco Tormena ; Italo Odone Mazali
• Associated research grant(s): 19/24445-8 - EMU granted in process 2018/25207-0: inductively coupled plasma mass spectrometer, AP.EMU
• Associated scholarship(s): 24/07971-6 - Exploring the coupling of inorganic and organic mass spectrometry equipment (HPLC-ESI-MS) and single-cell ICP-MS for the speciomics studies during the application of copper nanoparticles in the soybean callus cultivation, BP.PD; 24/08113-3 - Biosynthesis of Cu and bimetallic Cu and Ag nanoparticles and their uses in the cultivation of embryogenic soybean callus, BP.PD; 22/13166-3 - Nanoionomics applied to soybean cultivation, BP.IC; + associated scholarships 22/05673-2 - 3D DOSY experiments as a tool for mixture analysis, BP.IC; 22/02893-1 - Eco-friendly methods of metallic nanoparticles synthesis for application in evaluating soybean plants growth in the presence of the nanoparticles, BP.PD; 21/15218-8 - Nanometallomics applied to soybean cultivation, BP.PD; 22/00045-3 - Antioxidant stress responses of soybean plants grown in the presence of nanoparticles project (18/25207-0): Nanometalomics applied to soybean cultivation, BP.PD; 21/11685-0 - Ionomic and proteomic study in transgenic and non-transgenic soyebans grown in mercury doped soils in the presence of silicon nanoparticles as a remedial agent for toxic metal contamination, BP.DR; 22/01418-8 - Fast and environmental-friendly methods of silica nanoparticles synthesis for application in evaluating soybean plants growth in the presence of nanoparticles, BP.DD; 22/00104-0 - Nanoionomic evaluation of soybean plants cultured in soil with nanoparticles, BP.DD; 20/16038-0 - NMR applied to soybean cultivation metabolomics in the absence and presence of nanoparticles, BP.DD; 20/00133-4 - Cadmium-induced transgenerational effect on plants: a parental gift for progeny, BP.PD; 20/06934-9 - Characterization and quantification of silver and silica nanoparticles applied in soybean cultivation by a single part/cell ICP-MS/MS: translocation and cell interaction studies, BP.PD; 20/02020-2 - Characterization, determination and quantification of nanoparticles using single particle-Inductively Coupled Plasma Mass Spectrometry (sp-ICPMS), BP.DD - associated scholarships

Abstract

Different areas of production, such as food, agricultural and technological demand for products based on nanotechnology. This fact alerts the community about the possible effects that products composed of nanoparticles (NPs) can cause to the environment and, consequently, to living organisms. NPs may be present in biological systems and linked to molecules performing different functions on organisms and cells. Due to their high surface-volume ratio, NPs are highly reactive and catalytic, and can pass through cell membranes. However, their interactions with such systems are not yet well known. Despite this, some studies have warned about the possible effects of NPs, when in contact with some living organisms. In Brazil, there is no law that determines the permissible concentration of these in foods, as well as the discarding of NPs in the environment. In this way, through metallomics and other omics platforms, this project focus on the evaluation of the biological effects of the soybean plants, cultivated in the presence of silver, copper and silica nanoparticles, through macro characteristics of the plants, as growth, wet mass, germination rate, and others, as well as possible changes in terms of (metallo)proteins, lipids, enzymes and metals under the influence, or not, of NPs. (AU)

Scientific publications

(35)

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

PEREZ, MARIA B.; LIPINSKI, VICTOR M.; FILLIPINI, MARIA F.; CHACON MADRID, KATHERINE; ZEZZI ARRUDA, MARCO A.; WUILLOUD, RODOLFO G.. Distribution, accumulation and speciation of selenium at the different growth stages of four garlic clones. Food Additives and Contaminants Part A-Chemistry Analysis Control Exposure, JUN 2021. (18/25207-0)

DA COSTA, LUANA FERREIRA; ZEZZI ARRUDA, MARCO AURELIO. Simultaneous Hydride Generation Inductively Coupled Plasma Mass Spectrometry for the Evaluation of Different Generations of Soybean Seeds. BRAZILIAN JOURNAL OF ANALYTICAL CHEMISTRY, v. 10, n. 39, p. 11-pg., 2023-04-01. (17/50085-3, 19/24445-8, 14/50867-3, 19/00018-3, 18/25207-0, 20/08543-7)

DE CAMPOS, BRUNA K.; GALAZZI, RODRIGO M.; DOS SANTOS, BRUNA M.; BALBUENA, TIAGO S.; DOS SANTOS, FABIO N.; MOKOCHINSKI, JOAO B.; EBERLIN, MARCOS N.; ARRUDA, MARCO A. Z.. Comparison of generational effect on proteins and metabolites in non-transgenic and transgenic soybean seeds through the insertion of the cp4-EPSPS gene assessed by omics-based platforms. ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY, v. 202, OCT 1 2020. (13/17514-7, 18/25207-0, 16/07384-7, 13/15646-3)

RAFAEL L. GERMSCHEIDT; CLEIBER C. MORAIS; DANIELLE S. FRANCISCHINI; MARCO AURÉLIO Z. ARRUDA; JULIANO A. BONACIN. Photochemical Pre-Treatment to Quantify Iron in Thin Films. Journal of the Brazilian Chemical Society, v. 34, n. 7, p. 958-966, 2023-06-23. (14/50867-3, 19/24445-8, 21/05976-2, 13/22127-2, 19/00063-9, 19/00018-3, 17/11986-5, 17/23960-0, 17/50085-3, 18/25092-9, 18/25207-0)

DE ANDRADE, ALINE MARTINS; GALAZZI, RODRIGO MORETTO; MIRO, MANUEL; ZEZZI ARRUDA, ARCO AURELIO. In vitro bioaccessibility of metals from tape tea - A low-cost emerging drug. JOURNAL OF TRACE ELEMENTS IN MEDICINE AND BIOLOGY, v. 62, DEC 2020. (18/25207-0)

ARRUDA, MARCO AURELIO ZEZZI; DA SILVA, ANA BEATRIZ SANTOS; KATO, LILIAN SEIKO. There Is Plenty of Room in Plant Science: Nanobiotechnology as an Emerging Area Applied to Somatic Embryogenesis. Journal of Agricultural and Food Chemistry, v. N/A, p. 7-pg., 2023-02-14. (19/24445-8, 18/25207-0, 19/00018-3, 20/06934-9, 20/08543-7, 14/50867-3, 17/50085-3, 21/15218-8)

DE JESUS, JEMMYSON R.; LINHARES, LEONARDO A.; ARAGA, ANNELIZE Z. B.; ARRUDA, MARCO A. Z.; RAMOS, CARLOS H. I.. The stability and function of human cochaperone Hsp40/DNAJA1 are affected by zinc removal and partially restored by copper. Biochimie, v. 213, p. 7-pg., 2023-05-30. (17/26131-5, 19/24445-8, 14/50867-3, 18/00768-0, 18/25207-0, 20/08543-7)

PEREZ, MARIA B.; LIPINSKI, VICTOR M.; FILLIPINI, MARIA F.; CHACON MADRID, KATHERINE; ZEZZI ARRUDA, MARCO A.; WUILLOUD, RODOLFO G.. Distribution, accumulation and speciation of selenium at the different growth stages of four garlic clones. Food Additives and Contaminants Part A-Chemistry Analysis Control Exposure, v. 38, n. 9, p. 1506-1519, SEP 2 2021. (18/25207-0)

SILVA, ANA BEATRIZ SANTOS DA; ARRUDA, MARCO AURELIO ZEZZI. Single-cell ICP-MS to address the role of trace elements at a cellular level. JOURNAL OF TRACE ELEMENTS IN MEDICINE AND BIOLOGY, v. 75, p. 15-pg., 2023-01-01. (18/25207-0, 14/50867-3, 20/06934-9, 20/08543-7, 19/24445-8)

SILVA, ANA BEATRIZ SANTOS DA; ARRUDA, MARCO AURELIO ZEZZI. Exploring single-particle ICP-MS as an important tool for the characterization and quantification of silver nanoparticles in a soybean cell culture. SPECTROCHIMICA ACTA PART B-ATOMIC SPECTROSCOPY, v. 203, p. 9-pg., 2023-03-27. (19/24445-8, 20/06934-9, 14/50867-3, 18/25207-0, 20/08543-7)

QUINTELA, AMANDA L.; SANTOS, MARIA F. C.; DE LIMA, RODRIGO F.; MAYER, JULIANA L. S.; MARCHEAFAVE, GUSTAVO G.; ARRUDA, MARCO A. Z.; TORMENA, CLAUDIO F.. Influence of Silver Nanoparticles on the Metabolites of Two Transgenic Soybean Varieties: An NMR-Based Metabolomics Approach. Journal of Agricultural and Food Chemistry, v. 72, n. 21, p. 14-pg., 2024-05-15. (19/24445-8, 18/25207-0, 20/10246-0, 20/11463-5, 20/16038-0)

DE ANDRADE, ALINE MARTINS; DE BARROS, ANERISE; MAZALI, ITALO ODONE; ARRUDA, MARCO AURELIO ZEZZI. Fractionation and preconcentration of silver nanoparticles at environmentally relevant concentrations through induced eco-corona formation and spICP-MS characterization. ENVIRONMENTAL SCIENCE-NANO, v. 11, n. 4, p. 12-pg., 2024-02-02. (19/24445-8, 18/25207-0, 22/02893-1, 14/50867-3, 20/08543-7)

MARCHEAFAVE, GUSTAVO GALO; PAULI, ELIS DAIANE; TORMENA, CLAUDIA DOMICIANO; DUARTE, LEONARDO JOSE; WENDLING, IVAR; RAKOCEVIC, MIROSLAVA; QUINTELA, AMANDA LEMOS; SANTOS, MARIA DE FATIMA COSTA; TORMENA, CLAUDIO FRANCISCO; SCARMINIO, IEDA SPACINO; et al. ¹H NMR Mixture Design-Fingerprints and ASCA Analysis in Ilex paraguariensis: Model Stability in Search of a Global Metabolome. Analytical Chemistry, v. 95, n. 46, p. 11-pg., 2023-11-10. (18/25207-0, 20/10246-0, 22/14697-2, 20/11463-5, 20/16038-0)

MACHADO, EDUARDA Q.; FRANCISCHINI, DANIELLE DA S.; GALAZZI, RODRIGO M.; DE OLIVEIRA, CLEVERSON J. F.; ARRUDA, MARCO A. Z.. A minimal sample preparation for the determination of Ni and V in crude oil samples by LA-ICP-MS. Microchemical Journal, v. 210, p. 7-pg., 2025-03-01. (14/50867-3, 18/25207-0, 19/24445-8, 20/08543-7)

DA SILVA, ANA BEATRIZ SANTOS; LEAL, KETOLLY NATANNE DA SILVA; ARRUDA, MARCO AURELIO ZEZZI. An acidless microwave-assisted wet digestion of biological samples as a greener alternative: applications from COVID-19 monitoring to plant nanobiotechnology. ANALYTICAL AND BIOANALYTICAL CHEMISTRY, v. N/A, p. 12-pg., 2024-08-21. (19/24445-8, 18/25207-0, 14/50867-3, 20/08543-7, 20/06934-9)

FRANCISCHINI, DANIELLE DA SILVA; ARRUDA, MARCO AURELIO ZEZZI. One-point calibration and matrix-matching concept for quantification of potentially toxic elements in wood by LA-ICP-MS. ANALYTICAL AND BIOANALYTICAL CHEMISTRY, v. 416, n. 11, p. 12-pg., 2023-11-04. (17/50085-3, 19/24445-8, 18/25207-0, 14/50867-3, 20/08543-7, 19/00063-9)

LEAL, KETOLLY NATANNE DA SILVA; DA SILVA, ANA BEATRIZ SANTOS; FONSECA, ELISANIA KELLY BARBOSA; MOREIRA, OLIVIA BRITO DE OLIVEIRA; DE LEMOS, LUCIO MARCO; DE OLIVEIRA, MARCONE AUGUSTO LEAL; STEWART, ALAN J.; ARRUDA, MARCO AURELIO ZEZZI. Metallomic analysis of urine from individuals with and without Covid-19 infection reveals extensive alterations in metal homeostasis. JOURNAL OF TRACE ELEMENTS IN MEDICINE AND BIOLOGY, v. 86, p. 11-pg., 2024-12-01. (19/24445-8, 18/25207-0, 14/50867-3, 20/08543-7, 20/06934-9)

DE SOUZA PESSOA, GUSTAVO; DE JESUS, JEMMYSON ROMARIO; BALBUENA, TIAGO SANTANA; ARRUDA, MARCO AURELIO ZEZZI. Metallomics-based platforms for comparing the human blood serum profiles between bipolar disorder and schizophrenia patients. RAPID COMMUNICATIONS IN MASS SPECTROMETRY, v. 34, p. 10-pg., 2020-02-18. (14/50867-3, 18/25207-0, 16/07384-7)

FREITAS, DANIEL C.; DE ANDRADE, ALINE M.; DA COSTA, LUANA F.; AZEVEDO, RICARDO A.; ARRUDA, MARCO A. Z.. There is plenty of room at the plant science: A review of nanoparticles applied to plant cultures. Annals of Applied Biology, v. 178, n. 2, SI, p. 149-168, MAR 2021. (20/02020-2, 14/50867-3, 18/25207-0)

DE SOUZA PESSOA, GUSTAVO; DE JESUS, JEMMYSON ROMARIO; BALBUENA, TIAGO SANTANA; ARRUDA, MARCO AURELIO ZEZZI. Metallomics-based platforms for comparing the human blood serum profiles between bipolar disorder and schizophrenia patients. RAPID COMMUNICATIONS IN MASS SPECTROMETRY, FEB 2020. (14/50867-3, 18/25207-0, 16/07384-7)

FRANCISCHINI, DANIELLE DA SILVA; AMAIS, RENATA STABILE; STRIKIS, NICOLAS MISAILIDIS; ZEZZI ARRUDA, MARCO AURELIO. Qualitative Imaging of Elemental Spatial Distribution in Stalagmites through Laser Ablation Inductively Coupled Plasma Mass Spectrometry Analysis. BRAZILIAN JOURNAL OF ANALYTICAL CHEMISTRY, v. 10, n. 38, p. 12-pg., 2023-01-01. (17/50085-3, 19/24445-8, 19/00063-9, 18/23478-7, 18/25207-0)

FRANCISCHINI, DANIELLE S.; ARRUDA, MARCO A. Z.. When a picture is worth a thousand words: Molecular and elemental imaging applied to environmental analysis-A review. Microchemical Journal, v. 169, OCT 2021. (17/50085-3, 19/24445-8, 19/00063-9, 18/25207-0)

MOREAU, PEDRO DOS SANTOS; ZEZZI ARRUDA, MARCO AURELIO. Direct analysis of tree rings using laser ablation-ICP-MS and quantitative evaluation of Zn and Cu using filter paper as a solid support for calibration. Journal of Analytical Atomic Spectrometry, v. 37, n. 4, p. 10-pg., 2022-02-15. (19/00018-3, 18/25207-0, 14/50867-3, 17/50085-3, 19/24445-8)

ARRUDA, MARCO AURELIO ZEZZI; JESUS, JEMMYSON ROMARIO DE; BLINDAUER, CLAUDIA ANDREA; STEWART, ALAN JAMES. Speciomics as a concept involving chemical speciation and omics. JOURNAL OF PROTEOMICS, v. 263, p. 8-pg., 2022-07-15. (20/08543-7, 19/00018-3, 18/25207-0, 14/50867-3, 17/50085-3, 19/24445-8)

AMAIS, RENATA S.; DONATI, GEORGE L.; ZEZZI ARRUDA, MARCO A.. ICP-MS and trace element analysis as tools for better understanding medical conditions. TRAC-TRENDS IN ANALYTICAL CHEMISTRY, v. 133, DEC 2020. (18/23478-7, 18/25207-0, 14/50867-3)

DE JESUS, JEMMYSON ROMARIO; ZEZZI ARRUDA, MARCO AURELIO. Unravelling neurological disorders through metallomics-based approaches. METALLOMICS, v. 12, n. 12, p. 1878-1896, DEC 1 2020. (20/02020-2, 18/25207-0, 16/07384-7)

FREITAS, DANIEL CARNEIRO; MAZALI, ITALO ODONE; SIGOLI, FERNANDO APARECIDO; FRANCISCHINI, DANIELLE DA SILVA; ARRUDA, MARCO AURELIO ZEZZI. The microwave-assisted synthesis of silica nanoparticles and their applications in a soy plant culture. RSC ADVANCES, v. 13, n. 39, p. 9-pg., 2023-09-08. (19/24445-8, 19/00063-9, 14/50906-9, 14/50867-3, 19/00018-3, 21/06326-1, 18/25207-0, 20/08543-7)

FREITAS, DANIEL C.; DE ANDRADE, ALINE M.; DA COSTA, LUANA F.; AZEVEDO, RICARDO A.; ARRUDA, MARCO A. Z.. There is plenty of room at the plant science: A review of nanoparticles applied to plant cultures. Annals of Applied Biology, v. 178, n. 2, p. 20-pg., 2020-09-25. (20/02020-2, 14/50867-3, 18/25207-0)

DE JESUS, JEMMYSON ROMARIO; GALAZZI, RODRIGO MORETTO; LOPES JUNIOR, CICERO ALVES, JR.; ZEZZI ARRUDA, MARCO AURELIO. Trace element homeostasis in the neurological system after SARS-CoV-2 infection: Insight into potential biochemical mechanisms. JOURNAL OF TRACE ELEMENTS IN MEDICINE AND BIOLOGY, v. 71, p. 13-pg., 2022-02-28. (17/50085-3, 19/00063-9, 18/25207-0, 19/24445-8)

KATO, LILIAN SEIKO; DA SILVA, VINNICIUS HENRIQUE CERQUEIRA; DE ANDRADE, DIEGO CAMPACI; CRUZ, GUILHERME; PEDROBOM, JORGE HENRIQUE; RAAB, ANDREA; FELDMANN, JORG; ARRUDA, MARCO AURELIO ZEZZI. Multimodal chemical speciation techniques based on simultaneous high resolution molecular/atomic mass spectrometry applied to online target/ non-target analysis: A tutorial review. Analytica Chimica Acta, v. 1331, p. 29-pg., 2024-12-01. (21/11685-0, 19/24445-8, 18/25207-0, 14/50867-3, 20/08543-7, 21/15218-8)

CHACON-MADRID, KATHERINE; FRANCISCHINI, DANIELLE DA SILVA; ARRUDA, MARCO AURELIO ZEZZI. The role of silver nanoparticles effects in the homeostasis of metals in soybean cultivation through qualitative and quantitative laser ablation bioimaging. JOURNAL OF TRACE ELEMENTS IN MEDICINE AND BIOLOGY, v. 79, p. 7-pg., 2023-05-22. (17/50085-3, 19/24445-8, 19/00063-9, 14/50867-3, 18/25207-0, 20/08543-7)

ISCUISSATI, ISABELLE PEREIRA; GALAZZI, RODRIGO MORETTO; MIRO, MANUEL; ARRUDA, MARCO AURELIO ZEZZI. Evaluation of the aluminum migration from metallic seals to coffee beverage after using a high-pressure coffee pod machine. Journal of Food Composition and Analysis, v. 104, DEC 2021. (18/25207-0)

AMAIS, RENATA S.; MOREAU, PEDRO S.; FRANCISCHINI, DANIELLE S.; MAGNUSSON, RAFAEL; LOCOSSELLI, GIULIANO M.; GODOY-VEIGA, MILENA; CECCANTINI, GREGORIO; RODRIGUEZ, DAIGARD R. ORTEGA; TOMAZELLO-FILHO, MARIO; ARRUDA, MARCO A. Z.. Trace elements distribution in tropical tree rings through high-resolution imaging using LA-ICP-MS analysis. JOURNAL OF TRACE ELEMENTS IN MEDICINE AND BIOLOGY, v. 68, DEC 2021. (19/24445-8, 20/09251-0, 13/21728-2, 17/50085-3, 18/22914-8, 18/25207-0, 15/25511-3, 18/23478-7, 19/08783-0, 19/00063-9, 17/50341-0, 19/00018-3, 19/05174-3)

GERMSCHEIDT, RAFAEL LAVAGNOLLI; FRANCISCHINI, DANIELLE DA SILVA; SILVA, MARIANA BIANCHINI; ZEZZI ARRUDA, MARCO AURELIO; BARBOZA FORMIGA, ANDRE LUIZ; RIZUTI DA ROCHA, TULIO COSTA; BONACIN, JULIANO ALVES. Water Oxidation Performance Enhanced by Electrochemically Designed Vacancies on a Prussian Blue Catalyst. ACS APPLIED ENERGY MATERIALS, v. 5, n. 8, p. 8-pg., 2022-08-22. (17/50085-3, 17/11986-5, 18/25207-0, 14/50867-3, 19/00063-9)

LEAL, KETOLLY NATANNE DA SILVA; DA SILVA, ANA BEATRIZ SANTOS; ARAGAO, ANNELIZE ZAMBON BARBOSA; RAMOS, CARLOS HENRIQUE INACIO; STEWART, ALAN J.; ARRUDA, MARCO AURELIO ZEZZI. Optimizing the performance of single-cell ICP-MS/MS for Fe and Zn determination in human umbilical vascular endothelial cells. Microchemical Journal, v. 202, p. 10-pg., 2024-05-17. (19/24445-8, 18/25207-0, 17/26131-5, 14/50867-3, 20/08543-7, 20/06934-9)