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(Referência obtida automaticamente do Web of Science, por meio da informação sobre o financiamento pela FAPESP e o número do processo correspondente, incluída na publicação pelos autores.)

Sugarcane cystatins: From discovery to biotechnological applications

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Autor(es):
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Tanaka Shibao, Priscila Yumi [1, 2] ; Santos-Junior, Celio Dias [3, 1, 4] ; Santiago, Adelita Carolina [1] ; Mohan, Chakravarthi [1] ; Miguel, Mariana Cardoso [1] ; Toyama, Danyelle [1] ; Sanches Vieira, Marcos Antonio [5] ; Narayanan, Subramonian [6] ; Figueira, Antonio [7] ; Carmona, Adriana K. [8] ; Schiermeyer, Andreas [2] ; Soares-Costa, Andrea [1] ; Henrique-Silva, Flavio [1]
Número total de Autores: 13
Afiliação do(s) autor(es):
[1] Univ Fed Sao Carlos, Dept Genet & Evolut, Sao Carlos - Brazil
[2] Fraunhofer Inst Mol Biol & Appl Ecol IME, Aachen - Germany
[3] Fudan Univ, Inst Sci & Technol Brain Inspired Intelligence, Shanghai 200433 - Peoples R China
[4] Minist Educ, Key Lab Computat Neurosci & Brain Inspired Intell, Beijing - Peoples R China
[5] Univ Fed Sao Carlos, Ctr Agr Sci, Araras - Brazil
[6] ICAR Sugarcane Breeding Inst, Genet Transformat Lab, Div Crop Improvement, Coimbatore, Tamil Nadu - India
[7] Univ Sao Paulo, Ctr Nucl Energy Agr, Piracicaba, SP - Brazil
[8] Univ Fed Sao Paulo, Dept Biophys, Escola Paulista Med, Sao Paulo - Brazil
Número total de Afiliações: 8
Tipo de documento: Artigo de Revisão
Fonte: International Journal of Biological Macromolecules; v. 167, p. 676-686, JAN 15 2021.
Citações Web of Science: 0
Resumo

Phytocystatins are tight-binding cysteine protease inhibitors produced by plants. The first phytocystatin described was isolated from Oryza sativa and, since then, cystatins from several plant species were reported, including from sugarcane. Sugarcane cystatins were unraveled in Sugarcane EST project database, after sequencing of cDNA libraries from various sugarcane tissues at different developmental stages and six sugarcane cystatins were cloned, expressed and characterized (CaneCPI-1 to CaneCPI-6). These recombinant proteins were produced in different expression systems and inhibited several cysteine proteases, including human cathepsins B and L, which can be involved in pathologies, such as cancer. In this review, we summarize a comprehensive history of all sugarcane cystatins, presenting an updated phylogenetic analysis; chromosomal localization, and genomic organization. We also present protein docking of CaneCPI-5 in the active site of human cathepsin B, insights about canecystatins structures; recombinant expression in different systems, comparison of their inhibitory activities against human cysteine cathepsins B, K, L, S, V, falcipains from Plasmodium falciparum and a cathepsin L-like from the sugarcane weevil Sphenophorus levis; and enlighten their potential and current applications in agriculture and health. (C) 2020 Elsevier B.V. All rights reserved. (AU)

Processo FAPESP: 17/16118-1 - Produção de de canacistatina em vacúolos de cana-de-açúcar transgênica
Beneficiário:Priscila Yumi Tanaka Shibao
Modalidade de apoio: Bolsas no Brasil - Doutorado
Processo FAPESP: 19/11683-8 - Estudo da participação de proteases em processos patológicos
Beneficiário:Adriana Karaoglanovic Carmona
Modalidade de apoio: Auxílio à Pesquisa - Regular
Processo FAPESP: 15/10855-9 - Desenvolvimento de cana-de-açúcar transgênica mais resistente ao Sphenophorus levis
Beneficiário:Chakravarthi Mohan
Modalidade de apoio: Bolsas no Brasil - Pós-Doutorado
Processo FAPESP: 18/20051-2 - Produção de uma cistatina de cana-de-açúcar em Nicotiana benthamiana
Beneficiário:Priscila Yumi Tanaka Shibao
Modalidade de apoio: Bolsas no Exterior - Estágio de Pesquisa - Doutorado