Hepatotoxic and neuroendocrine effects in physicians occupationally exposed to most modern halogenated anesthetics and nitrous oxide

Autor(es)

Aun, Aline G. ^[1] ; Souza, Katina M. ^[1] ; Guedes, Julia L. ^[1] ; Figueiredo, Drielle B. S. ^[1] ; Lara, Juliana R. ^[1] ; Silva, Mariane A. P. ^[1] ; Braz, Leandro G. ^[1] ; Braz, Mariana G. ^[1]

Afiliação do(s) autor(es)

^[1] Sao Paulo State Univ Unesp, Med Sch, Dept Anesthesiol, Botucatu, SP - Brazil

• Tipo de documento: Artigo Científico
• Fonte: ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY; v. 81, JAN 2021.
• Citações Web of Science: 0

Resumo

The lack of data on hepatic and hormonal markers for occupational exposure to most modern halogenated anesthetics has stimulated our research, which assessed liver enzymes, high-sensitivity C-reactive protein (hs-CRP) and neuroendocrine response. The study investigated 106 physicians who were categorized in an exposed group (primarily exposed to isoflurane and sevoflurane and less to desflurane and nitrous oxide) as well as as a control group. Anesthetic air monitoring was performed, and biological samples were analyzed for the most important liver enzymes, hs-CRP, adrenocorticotrophic hormone, cortisol and prolactin. No biomarkers were significantly different between the groups. Exposed males showed significant increases in cortisol and prolactin compared to unexposed males. However, values were within the reference ranges, and 22 % of exposed males versus 5 % of unexposed males exhibited higher prolactin values above the reference range. This study suggests that occupational exposure to the most commonly used inhalational anesthetics is not associated with hepatotoxicity or neurohormonal changes. (AU)

• Processo FAPESP: 16/15559-1 - Avaliação de status redox, resposta inflamatória, telômeros e expressão gênica em anestesiologistas
• Beneficiário: Mariana Gobbo Braz
• Modalidade de apoio: Auxílio à Pesquisa - Regular
• Processo FAPESP: 16/23902-8 - Avaliação de status redox, resposta inflamatória, telômeros e expressão gênica em anestesiologistas
• Beneficiário: Kátina Meneghetti de Souza
• Modalidade de apoio: Bolsas no Brasil - Doutorado
• Processo FAPESP: 18/20143-4 - Monitoramento genotóxico, citotóxico, oxidativo e neuro-imune-endócrino em profissionais expostos aos resíduos de gases anestésicos durante a residência médica
• Beneficiário: Leandro Gobbo Braz
• Modalidade de apoio: Auxílio à Pesquisa - Regular
• Processo FAPESP: 17/21504-8 - Avaliação de parâmetros hematológicos, bioquímicos e de sistema antioxidante em médicos expostos aos resíduos de gases anestésicos durante a residência médica
• Beneficiário: Júlia Lisbôa Guedes
• Modalidade de apoio: Bolsas no Brasil - Iniciação Científica