Re(V) complexes containing the phenylimido (NPh2-) core and SNS-thiosemicarbazide ligands

Autor(es)

Borges, Alice P. ^[1] ; Possato, Bruna ^[2] ; Hagenbach, Adelheid ^[2] ; Machado, Antonio E. H. ^[3] ; Deflon, Victor M. ^[4] ; Abram, Ulrich ^[2] ; Maia, Pedro I. S. ^[1]

Afiliação do(s) autor(es)

^[1] Univ Fed Triangulo Mineiro, Nucleo Desenvolvimento Compostos Bioat NDCBio, Av Dr Randolfo Borges 1400, BR-38025440 Uberaba, MG - Brazil

^[2] Free Univ Berlin, Inst Chem & Biochem, Fabeckstr 34-36, D-14195 Berlin - Germany

^[3] Fed Univ Uberlandia UFU, Inst Chem, BR-38400902 Uberlandia, MG - Brazil

^[4] Univ Sao Paulo, Inst Quim Sao Carlos, Av Trabalhador Sao Carlense 400, BR-13566590 Sao Carlos, SP - Brazil

• Tipo de documento: Artigo Científico
• Fonte: Inorganica Chimica Acta; v. 516, FEB 1 2021.
• Citações Web of Science: 0

Resumo

Reactions of thiosemicarbazone ligands (H2L1) with {[}ReX3(NPh)(PPh3)(2)] (X = Cl or Br) led to the formation of stable rhenium(V) complexes of composition {[}ReX(NPh)(HL1)(PPh3)]X. The Re(V) complexes have been characterized by diverse techniques including FTIR, H-1 and P-31 NMR, elemental analysis, HRMS and single-crystal X-ray diffraction analysis. The crystal structures of the complexes rhenium complexes showed the formation a distorted octahedron environment around the Re(V) metal center, with the axial positions being occupied by the halogen atom and by the nitrogen atom from the phenylimido moiety, while the equatorial positions are occupied by the S,N,S-thiosemicarbazonate and the triphenylphosphane ligands. Furthermore, the ``3 + 2{''} mixed ligand complex {[}Re(NPh)(L1b)(Et(2)btu)], where HEt(2)btu is N,N-diethyl-N'-benzoylthiourea, could be obtained from an equimolar reaction of {[}ReCl(NPh)(HL1)(PPh3)]Cl with the bidentate thiourea in the presence of NEt3. Finally, DFT calculations were applied in order to propose a complex suitable for biocouplings upon substitution of a NH(2 )group at the 4-position of the phenylimido ligand in {[}Re(NPh)(L1b)(Et(2)btu)]. The compounds studied here represent the first examples of phenilimidorhenium(V) complexes with thiosemicarbazones. (AU)

• Processo FAPESP: 09/54011-8 - EMU: aquisição de difratômetro de raios X de monocristal para análise estrutural de moléculas pequenas e proteínas
• Beneficiário: Victor Marcelo Deflon
• Modalidade de apoio: Auxílio à Pesquisa - Programa Equipamentos Multiusuários
• Processo FAPESP: 19/19835-1 - Avaliação de novas tioureias relacionadas à melatonina e seus complexos metálicos como potenciais agentes tripanocidas: síntese e caracterização
• Beneficiário: Bruna Possato Dezsa
• Modalidade de apoio: Bolsas no Exterior - Estágio de Pesquisa - Pós-Doutorado