Effect of sevoflurane on the inflammatory response during cardiopulmonary bypass in cardiac surgery: the study protocol for a randomized controlled trial

Autor(es)

Azevedo Maranhao Cardoso, Thiago Augusto ^[1] ; Kunst, Gudrun ^[2] ; Neto, Caetano Nigro ^[1] ; Costa Junior, Jose de Ribamar ^[3] ; Santos Silva, Carlos Gustavo ^[1] ; Bastos, Gisele Medeiros ^[4] ; Borges, Jessica Bassani ^[4] ; Hirata, Mario Hiroyuki ^[5]

Afiliação do(s) autor(es)

^[1] Dante Pazzanese Inst Cardiol, Dept Surg & Anesthesia, Captain Pinto Ferreira St, 62, Ap 92, BR-01423020 Sao Paulo - Brazil

^[2] Kings Coll Hosp NHS Fdn Trust, Dept Anaesthet Intens Care Med & Pain Therapy, Intens Care Med & Pain Therapy, Denmark Hill, London - England

^[3] Dante Pazzanese Inst Cardiol, Dept Intervent Cardiol, Sao Paulo - Brazil

^[4] Dante Pazzanese Inst Cardiol, Mol Cardiol Res Lab, Sao Paulo - Brazil

^[5] Univ Sao Paulo, Sch Pharmaceut Sci, Dept Clin & Toxicol Anal, Sao Paulo - Brazil

• Tipo de documento: Artigo Científico
• Fonte: Trials; v. 22, n. 1 JAN 6 2021.
• Citações Web of Science: 0

Resumo

BackgroundRecent experimental evidence shows that sevoflurane can reduce the inflammatory response during cardiac surgery with cardiopulmonary bypass. However, this observation so far has not been assessed in an adequately powered randomized controlled trial.MethodsWe plan to include one hundred patients undergoing elective coronary artery bypass graft with cardiopulmonary bypass who will be randomized to receive either volatile anesthetics during cardiopulmonary bypass or total intravenous anesthesia. The primary endpoint of the study is to assess the inflammatory response during cardiopulmonary bypass by measuring PMN-elastase serum levels. Secondary endpoints include serum levels of other pro-inflammatory markers (IL-1 beta, IL-6, IL-8, TNF alpha), anti-inflammatory cytokines (TGF beta and IL-10), and microRNA expression in peripheral blood to achieve possible epigenetic mechanisms in this process. In addition clinical endpoints such as presence of major complications in the postoperative period and length of hospital and intensive care unit stay will be assessed.DiscussionThe trial may determine whether adding volatile anesthetic during cardiopulmonary bypass will attenuate the inflammatory response.Trial registrationClinicalTrials.gov NCT02672345. Registered on February 2016 and updated on June 2020. (AU)

• Processo FAPESP: 17/21306-1 - Relação entre fatores epigenéticos e a ação do anestésico Sevofluorano.
• Beneficiário: José de Ribamar Costa Júnior
• Modalidade de apoio: Auxílio à Pesquisa - Regular