| Texto completo | |
| Autor(es): |
Dieng, Idrissa
[1]
;
dos Passos Cunha, Marielton
[2]
;
Diagne, Moussa Moise
[1]
;
Sembene, Pape Mbacke
[3, 4]
;
de Andrade Zanotto, Paolo Marinho
[2]
;
Faye, Ousmane
[1]
;
Faye, Oumar
[1]
;
Sall, Amadou Alpha
[1]
Número total de Autores: 8
|
| Afiliação do(s) autor(es): | [1] Inst Pasteur, Virol Dept, Arboviruses & Haemorrhag Fever Viruses Unit, BP 220, Dakar - Senegal
[2] Univ Sao Paulo, Biomed Sci Inst, Dept Microbiol, Lab Mol Evolut & Bioinformat, BR-05508000 Sao Paulo - Brazil
[3] Univ Cheikh Anta Diop Dakar UCAD, Fac Sci & Tech, Dept Anim Biol, Fann BP 5005, Dakar - Senegal
[4] UCAD, ISRA, CBGP, BIOPASS, IRD, Campus Bel Air, BP 1386, Dakar 18524 - Senegal
Número total de Afiliações: 4
|
| Tipo de documento: | Artigo Científico |
| Fonte: | Viruses-Basel; v. 13, n. 1 JAN 2021. |
| Citações Web of Science: | 0 |
| Resumo | |
Dengue virus (DENV) is the most widespread arthropod-borne virus, with the number and severity of outbreaks increasing worldwide in recent decades. Dengue is caused by genetically distinct serotypes, DENV-1-4. Here, we present data on DENV-1, isolated from patients with dengue fever during an outbreak in Senegal and Mali (Western Africa) in 2015-2019, that were analyzed by sequencing the envelope (E) gene. The emergence and the dynamics of DENV-1 in Western Africa were inferred by using maximum likelihood and Bayesian methods. The DENV-1 grouped into a monophyletic cluster that was closely related to those from Southeast Asia. The virus appears to have been introduced directly into Medina Gounass (Suburb of Dakar), Senegal (location probability = 0.301, posterior = 0.76). The introduction of the virus in Senegal occurred around 2014 (95% HPD = 2012.88-2014.84), and subsequently, the virus moved to regions within Senegal (e.g., Louga and Fatick), causing intense outbreaks in the subsequent years. The virus appears to have been introduced in Mali (a neighboring country) after its introduction in Senegal. In conclusion, we present evidence that the outbreak caused by DENV-1 in urban environments in Senegal and Mali after 2015 was caused by a single viral introduction from Asia. (AU) | |
| Processo FAPESP: | 16/08204-2 - Diversidade genética e filodinâmica dos arbovírus emergentes e reemergentes (DENV, ZIKV e CHIKV) nas regiões Nordeste e Sudeste do Brasil, 2014-2016 |
| Beneficiário: | Marielton dos Passos Cunha |
| Modalidade de apoio: | Bolsas no Brasil - Doutorado |
| Processo FAPESP: | 17/23281-6 - Utilização de anticorpos que neutralizam a infecção após a adesão à célula para o desenvolvimento de estratégias imunoterápicas inovadoras exemplificadas pela destruição seletiva de células humanas infectadas pelo vírus Zika. |
| Beneficiário: | Paolo Marinho de Andrade Zanotto |
| Modalidade de apoio: | Auxílio à Pesquisa - Regular |