A novel Ag doping Ti alloys route: Formation and antibacterial effect of the TiO2 nanotubes

Autor(es)

Taipina, Marcia O. ^[1] ; de Mello, Mariana G. ^[2] ; Tamborlin, Leticia ^{[3, 2]} ; Pereira, Karina D. ^{[3, 2]} ; Luchessi, Augusto D. ^{[3, 2]} ; Cremasco, Alessandra ^[2] ; Caram, Rubens ^[1]

Afiliação do(s) autor(es)

^[1] Univ Campinas UNICAMP, Sch Mech Engn Campinas, BR-13083860 Campinas, SP - Brazil

^[2] Univ Campinas UNICAMP, Sch Appl Sci Limeira, BR-13484350 Campinas, SP - Brazil

^[3] Sao Paulo State Univ UNESP, Inst Biosci, BR-13506900 Rio Claro, SP - Brazil

• Tipo de documento: Artigo Científico
• Fonte: Materials Chemistry and Physics; v. 261, MAR 1 2021.
• Citações Web of Science: 0

Resumo

Titanium has been widely used for clinical purposes, but post-surgical infections remain a troublesome issue, impairing patient's quality of life. Silver (Ag) is a potent broad-spectrum antimicrobial agent whose disinfecting effect has been known for centuries. In light of this fact, as an attempt to provide a long-term solution to prevent implant-associated infection, we produced Ti-35Nb alloys containing Ag, using different methods to incorporate it. These alloys were subjected to an electrochemical process to produce TiO2 nanotubes on their surface, in an attempt to further improve the material's bioactivity. Also, on the Ti-35Nb substrate, TiO2 nanotubes were grown and then decorated with Ag by UV light-induced photoreduction. The results indicate that Ag does not affect the formation of TiO2 arrays. Furthermore, the results show that added Ag can elicit antibacterial activity without leaching significant amounts of Ag that are considered toxic to mammalian cells. An initial cytotoxicity evaluation was conducted with pre-osteoblast cell line (MC3T3-E1) and its viability profile was indirectly assessed by MTT assay. Results indicate that the presence of TiO2 improves osteoblast proliferation and that Ag addition seems to mostly promote cell proliferation. (AU)

• Processo FAPESP: 19/06951-3 - Rastreamento das ações moleculares do aminoácido hipusina
• Beneficiário: Augusto Ducati Luchessi
• Modalidade de apoio: Auxílio à Pesquisa - Regular
• Processo FAPESP: 16/24693-3 - Precipitação Não-clássica da Fase Alfa em Ligas Ti-Nb-Fe e Ti-Nb-Fe-Sn
• Beneficiário: Rubens Caram Junior
• Modalidade de apoio: Auxílio à Pesquisa - Regular
• Processo FAPESP: 17/21914-1 - Caracterização funcional do aminoácido hipusina
• Beneficiário: Leticia Tamborlin
• Modalidade de apoio: Bolsas no Brasil - Doutorado
• Processo FAPESP: 14/00159-2 - Estudo eletroquímico de ligas de Ti beta metaestáveis revestidas com filmes nanoestruturados de TiO2
• Beneficiário: Alessandra Cremasco
• Modalidade de apoio: Auxílio à Pesquisa - Regular