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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

A novel Ag doping Ti alloys route: Formation and antibacterial effect of the TiO2 nanotubes

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Taipina, Marcia O. [1] ; de Mello, Mariana G. [2] ; Tamborlin, Leticia [3, 2] ; Pereira, Karina D. [3, 2] ; Luchessi, Augusto D. [3, 2] ; Cremasco, Alessandra [2] ; Caram, Rubens [1]
Total Authors: 7
[1] Univ Campinas UNICAMP, Sch Mech Engn Campinas, BR-13083860 Campinas, SP - Brazil
[2] Univ Campinas UNICAMP, Sch Appl Sci Limeira, BR-13484350 Campinas, SP - Brazil
[3] Sao Paulo State Univ UNESP, Inst Biosci, BR-13506900 Rio Claro, SP - Brazil
Total Affiliations: 3
Document type: Journal article
Source: Materials Chemistry and Physics; v. 261, MAR 1 2021.
Web of Science Citations: 0

Titanium has been widely used for clinical purposes, but post-surgical infections remain a troublesome issue, impairing patient's quality of life. Silver (Ag) is a potent broad-spectrum antimicrobial agent whose disinfecting effect has been known for centuries. In light of this fact, as an attempt to provide a long-term solution to prevent implant-associated infection, we produced Ti-35Nb alloys containing Ag, using different methods to incorporate it. These alloys were subjected to an electrochemical process to produce TiO2 nanotubes on their surface, in an attempt to further improve the material's bioactivity. Also, on the Ti-35Nb substrate, TiO2 nanotubes were grown and then decorated with Ag by UV light-induced photoreduction. The results indicate that Ag does not affect the formation of TiO2 arrays. Furthermore, the results show that added Ag can elicit antibacterial activity without leaching significant amounts of Ag that are considered toxic to mammalian cells. An initial cytotoxicity evaluation was conducted with pre-osteoblast cell line (MC3T3-E1) and its viability profile was indirectly assessed by MTT assay. Results indicate that the presence of TiO2 improves osteoblast proliferation and that Ag addition seems to mostly promote cell proliferation. (AU)

FAPESP's process: 19/06951-3 - Screening of the amino acid hypusine molecular actions
Grantee:Augusto Ducati Luchessi
Support type: Regular Research Grants
FAPESP's process: 16/24693-3 - Non-classic Precipitation of Alpha Phase in Ti-Nb-Fe and Ti-Nb-Fe-Sn Alloys
Grantee:Rubens Caram Junior
Support type: Regular Research Grants
FAPESP's process: 17/21914-1 - Functional characterization of the amino acid hypusine
Grantee:Leticia Tamborlin
Support type: Scholarships in Brazil - Doctorate
FAPESP's process: 14/00159-2 - Electrochemical study of beta metastable titanium alloys coated with TiO2 nanostructured films
Grantee:Alessandra Cremasco
Support type: Regular Research Grants