The involvement of renal afferents in the maintenance of cardiorenal diseases

Autor(es)

Veiga, Amanda C. ^[1] ; Milanez, Maycon I. O. ^[1] ; Campos, Ruy R. ^[1] ; Bergamaschi, Cassia T. ^[1] ; Nishi, Erika E. ^[1]

Afiliação do(s) autor(es)

^[1] Univ Fed Sao Paulo, Dept Physiol, Cardiovasc Div, Escola Paulista Med, Sao Paulo - Brazil

• Tipo de documento: Artigo de Revisão
• Fonte: AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY; v. 320, n. 1, p. R88-R93, JAN 2021.
• Citações Web of Science: 0

Resumo

Elevated sympathetic vasomotor activity is a common feature of cardiorenal diseases. Therefore, the sympathetic nervous system is an important therapeutic target, particularly the fibers innervating the kidneys. In fact, renal denervation has been applied clinically and shown promising results in patients with hypertension and chronic kidney disease. However, the underlying mechanisms involved in the cardiorenal protection induced by renal denervation have not yet been fully clarified. This mini-review highlights historical and recent aspects related to the role of renal sensory fibers in the control of cardiorenal function under normal conditions and in experimental models of cardiovascular disease. Results have demonstrated that alterations in renal sensory function participate in the maintenance of elevated sympathetic vasomotor activity and cardiorenal changes; as such, renal sensory fibers may be a potential therapeutic target for the treatment of cardiorenal diseases. Although it has not yet been applied in clinical practice, selective afferent renal denervation may be promising, since such an approach maintains efferent activity and can provide more refined control of renal function compared with total renal denervation. However, more studies are needed to understand the mechanisms by which renal afferents partially contribute to such changes, in addition to the need to evaluate the safety and advantages of the approach for application in the clinical practice. (AU)

• Processo FAPESP: 18/01898-4 - Avaliação das projeções encéfalo-espinais no estabelecimento temporal da hiperativação simpática renal na Hipertensão Renovascular
• Beneficiário: Maycon Igor de Oliveira Milanez
• Modalidade de apoio: Bolsas no Brasil - Doutorado
• Processo FAPESP: 18/02671-3 - Ações funcionais e moleculares do nervo renal na doença renal crônica experimental
• Beneficiário: Cassia Marta de Toledo Bergamaschi
• Modalidade de apoio: Auxílio à Pesquisa - Regular
• Processo FAPESP: 18/11909-3 - Efeitos da denervação renal em um modelo de doença renal crônica
• Beneficiário: Amanda Costa Veiga
• Modalidade de apoio: Bolsas no Brasil - Mestrado
• Processo FAPESP: 17/03905-5 - Avaliação da influência da inervação aferente renal na insuficiência renal crônica experimental
• Beneficiário: Amanda Costa Veiga
• Modalidade de apoio: Bolsas no Brasil - Iniciação Científica