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(Referência obtida automaticamente do Web of Science, por meio da informação sobre o financiamento pela FAPESP e o número do processo correspondente, incluída na publicação pelos autores.)

Chronic Escitalopram Treatment Does Not Alter the Effects of Neonatal Stress on Hippocampal BDNF Levels, 5-HT(1A)Expression and Emotional Behaviour of Male and Female Adolescent Rats

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Autor(es):
Henn, Lorena [1] ; Zanta, Natalia C. [1] ; Girardi, Carlos Eduardo N. [1] ; Suchecki, Deborah [1]
Número total de Autores: 4
Afiliação do(s) autor(es):
[1] Univ Fed Sao Paulo, Dept Psicobiol, Rua Napoleao Barros 925, 1 Andar, BR-04024002 Sao Paulo, SP - Brazil
Número total de Afiliações: 1
Tipo de documento: Artigo Científico
Fonte: Molecular Neurobiology; v. 58, n. 3, p. 926-943, MAR 2021.
Citações Web of Science: 0
Resumo

Early life stress is considered a risk factor for the development of long-term psychiatric disorders. Maternal deprivation (MD) is a useful paradigm to understand the neurobiological underpinnings of early stress-induced changes in neurodevelopment trajectory. The goal of the present study was to examine the effects of a chronic treatment with escitalopram (ESC) on the hippocampal levels of BDNF and neuropeptide Y (NPY), expression of serotonin type 1A receptor (5-HT1A), plasma corticosterone levels and emotional behaviours in male and female adolescent rats submitted to MD at 9 days of life (group DEP9) and challenged with a brief and mild stress (saline injection (SAL)) at the end of MD. Whole litters were kept with mothers (CTL) or submitted to MD (DEP9). Within each group, pups were stress-challenged (CTL-SAL and DEP9-SAL) or not (CTL-NSAL and DEP9-NSAL). ESC or vehicle treatments began at weaning and lasted 24 days, when animals were sacrificed for determination of neurobiological variables or submitted to a battery of tests for evaluation of emotional behaviours. The results showed that BDNF levels were higher in SAL-challenged males and in DEP9-SAL females, whereas 5-HT(1A)receptor expression was reduced in DEP9 males and in SAL-challenged females. There were no changes in NPY or corticosterone levels. In the forced swim test, SAL-challenged males and DEP9 females displayed less immobility and ESC only increased social motivation in males. The results indicated that neonatal stress led to sex-dependent changes in neurobiology and behaviour and that chronic ESC treatment had minor effects on these parameters. (AU)

Processo FAPESP: 15/24745-0 - Efeito do tratamento com escitalopram sobre as alterações comportamentais decorrentes da privação materna no dia pós-natal 9 em ratos Wistar
Beneficiário:Natália Cristina Zanta
Modalidade de apoio: Bolsas no Brasil - Mestrado
Processo FAPESP: 15/26364-4 - Mecanismos neurobiológicos envolvidos nas consequências emocionais tardias da privação maternal
Beneficiário:Deborah Suchecki
Modalidade de apoio: Auxílio à Pesquisa - Regular