Low dose of Jucara pulp (Euterpe edulis Mart.) minimizes the colon inflammatory milieu promoted by hypercaloric and hyperlipidic diet in mice

Autor(es):Mostrar menos -

Silva, F. P. ^[1] ; De Miranda, D. A. ^[1] ; Carnier, M. ^[1] ; Maza, P. K. ^[1] ; Boldarine, V. T. ^[1] ; Rischiteli, A. B. Silva ^[1] ; Avila, F. ^[1] ; Pontes, L. P. P. ^[1] ; Hachul, A. C. L. ^[1] ; Neto, N. I. P. ^[1] ; Ribeiro, E. B. ^[1] ; Oller do Nascimento, C. M. ^[1] ; de Rosso, V. V. ^[2] ; Oyam, L. M. ^[1]

Afiliação do(s) autor(es)

^[1] Univ Fed Sao Paulo, Dept Fisiol, Escola Paulista Med, Sao Paulo, SP - Brazil

^[2] Univ Fed Sao Paulo, Dept Biociencias, Inst Saude & Soc, Santos, SP - Brazil

• Tipo de documento: Artigo Científico
• Fonte: Journal of Functional Foods; v. 77, FEB 2021.
• Citações Web of Science: 0

Resumo

Obesity is a multifactorial disease with a genesis including the ingestion of hypercaloric diet rich in fat, ultra processed food, poor in micronutrients and fiber. Some food rich in bioactive compounds are studies to prove their capacity to decrease the deleterious metabolic effect promoted by refined sugar and fat rich-diet. The goal of this study was to evaluate the effect of Jucara (Euterpe edulis Mart.) supplementation, a fruit rich in fiber and bioactive compounds, mostly anthocyanin, on systemic inflammation in obese mice. Swiss mice were treated with hyperlipidic and hypercaloric diet supplemented or not with 0.5% and 2% of jucara pulp for sixteen weeks. Pro and anti-inflammatory cytokines were evaluated in different tissues. The results showed that sixteen weeks of treatment with hyperlipidic and hypercaloric diet were efficient in developing obesity in mice and jucara supplementation decreased the pro-inflammatory cytokines and TLR-4 protein content in the colon. (AU)

• Processo FAPESP: 17/13108-5 - Efeito da administração da polpa de juçara (Euterpe edulis Mart) na permeabilidade intestinal de camundongos tratados com dieta hiperlipídica e hipercalórica
• Beneficiário: Eliane Beraldi Ribeiro
• Modalidade de apoio: Auxílio à Pesquisa - Regular