Alzheimer's Disease: Related Targets, Synthesis of Available Drugs, Bioactive Compounds Under Development and Promising Results Obtained from Multi-target Approaches

Autor(es)

Pirolla, Natalia F. F. ^[1] ; Batista, Victor S. ^[1] ; Dias Viegas, Flavia Pereira ^[2] ; Gontijo, Vanessa Silva ^[2] ; McCarthy, Caitlin R. ^{[1, 3]} ; Viegas Jr, Claudio ; Nascimento-Junior, Nailton M. ^[1]

Afiliação do(s) autor(es)

^[1] Sao Paulo State Univ UNESP, Inst Chem, Dept Biochem & Organ Chem, Lab Med Chem Organ Synth & Mol Modelling LaQMedSO, Rua Prof Francisco Degni 55, BR-14800060 Araraquara, SP - Brazil

^[2] Univ Fed Alfenas, Inst Chem, Lab Res Med Chem Istry PeQuiM, BR-37133840 Alfenas, MG - Brazil

^[3] Univ Victoria, 3800 Finnerty Rd, Victoria, BC V8P 5C2 - Canada

• Tipo de documento: Artigo de Revisão
• Fonte: CURRENT DRUG TARGETS; v. 22, n. 5, p. 505-538, 2021.
• Citações Web of Science: 0

Resumo

We describe herein the therapeutic targets involved in Alzheimer's disease as well as the available drugs and their synthetic routes. Bioactive compounds under development are also exploited to illustrate some recent research advances on the medicinal chemistry of Alzheimer's disease, including structure-activity relationships for some targets. The importance of multi-target approaches, including some examples from our research projects, guides new perspectives in search of more effective drug candidates. This review comprises the period between 2001 and early 2020. (AU)

• Processo FAPESP: 18/00187-7 - Planejamento, estudos computacionais, síntese e avaliação farmacológica de novas substâncias bioativas frente aos receptores de nicotínicos de acetilcolina alfa7 e alfa4beta2
• Beneficiário: Nailton Monteiro Do Nascimento Júnior
• Modalidade de apoio: Auxílio à Pesquisa - Regular