The Hallmarks of Flavonoids in Cancer

Autor(es)

Ponte, Luis Gustavo Saboia ^[1] ; Pavan, Isadora Carolina Betim ^{[1, 2]} ; Mancini, Mariana Camargo Silva ^[1] ; da Silva, Luiz Guilherme Salvino ^[1] ; Morelli, Ana Paula ^[1] ; Severino, Matheus Brandemarte ^[1] ; Bezerra, Rosangela Maria Neves ^[1] ; Simabuco, Fernando Moreira ^[1]

Afiliação do(s) autor(es)

^[1] Univ Campinas UNICAMP, Sch Appl Sci FCA, Multidisciplinary Lab Food & Hlth LabMAS, BR-13484350 Limeira, SP - Brazil

^[2] Univ Campinas UNICAMP, Sch Pharmaceut Sci FCF, Lab Signal Mech LMS, BR-13083871 Campinas, SP - Brazil

• Tipo de documento: Artigo de Revisão
• Fonte: Molecules; v. 26, n. 7 APR 2021.
• Citações Web of Science: 3

Resumo

Flavonoids represent an important group of bioactive compounds derived from plant-based foods and beverages with known biological activity in cells. From the modulation of inflammation to the inhibition of cell proliferation, flavonoids have been described as important therapeutic adjuvants against several diseases, including diabetes, arteriosclerosis, neurological disorders, and cancer. Cancer is a complex and multifactor disease that has been studied for years however, its prevention is still one of the best known and efficient factors impacting the epidemiology of the disease. In the molecular and cellular context, some of the mechanisms underlying the oncogenesis and the progression of the disease are understood, known as the hallmarks of cancer. In this text, we review important molecular signaling pathways, including inflammation, immunity, redox metabolism, cell growth, autophagy, apoptosis, and cell cycle, and analyze the known mechanisms of action of flavonoids in cancer. The current literature provides enough evidence supporting that flavonoids may be important adjuvants in cancer therapy, highlighting the importance of healthy and balanced diets to prevent the onset and progression of the disease. (AU)

• Processo FAPESP: 18/08391-2 - Estudo funcional e molecular da cinase humana NEK6 como alvo de drogas contra Câncer de Próstata
• Beneficiário: Isadora Carolina Betim Pavan
• Modalidade de apoio: Bolsas no Brasil - Doutorado
• Processo FAPESP: 19/00607-9 - Caracterização de alvos moleculares envolvidos na resistência quimioterápica e no metabolismo tumoral de células de câncer de pulmão
• Beneficiário: Ana Paula Morelli
• Modalidade de apoio: Bolsas no Brasil - Mestrado
• Processo FAPESP: 19/25582-9 - Estudo do papel da proteína Nrf2 na regulação do metabolismo e controle redox em resposta a compostos naturais derivados de alimentos em células de Câncer de Próstata
• Beneficiário: Mariana Camargo Silva Mancini
• Modalidade de apoio: Bolsas no Brasil - Doutorado Direto
• Processo FAPESP: 18/14818-9 - Estudo de alvos moleculares importantes para o controle do metabolismo em câncer: a via da mTOR/S6K com papel central
• Beneficiário: Fernando Moreira Simabuco
• Modalidade de apoio: Auxílio à Pesquisa - Jovens Pesquisadores - Fase 2