COVID-19 (SARS-CoV-2) infection and thrombotic conditions: A systematic review and meta-analysis

Autor(es)

Gabbai-Armelin, Paulo Roberto ^[1] ; de Oliveira, Analu Barros ^[1] ; Ferrisse, Tulio Morandin ^[1] ; Sales, Luciana Solera ^[1] ; Barbosa, Elis Rodrigues Oliveira ^[1] ; Miranda, Marina Lins ^[1] ; Salomao, Karina Borges ^[1] ; Brighenti, Fernanda Lourencao ^[1]

Afiliação do(s) autor(es)

^[1] Sao Paulo State Univ Unesp, Sch Dent, BR-14801903 Araraquara, SP - Brazil

• Tipo de documento: Artigo de Revisão
• Fonte: EUROPEAN JOURNAL OF CLINICAL INVESTIGATION; v. 51, n. 6 APR 2021.
• Citações Web of Science: 2

Resumo

Background COVID-19 is an infectious disease caused by SARS-CoV-2 associated with haematological manifestations (thrombolytic events). Aims Considering the high prevalence of the thrombotic scenarios associated with COVID-19, the aim of this study was to perform a systematic review of the available literature, concerning the relation of COVID-19 and the thrombotic events, and identify prognostic factors for these events. Materials \& Methods PubMed, Web of Science and Scopus databases were searched. Independent reviewers conducted all flow diagram steps. For qualitative analysis, Oxford level of evidence and Newcastle-Ottawa scale were used in the eligible articles. For the prognostic factors, a meta-analysis was conducted to age, number of neutrophils and platelets, and levels of ferritin, C-reactive protein, lactate dehydrogenase and D-dimer. Publication bias was accessed by funnel plot and by trim-and-fill test. Trim-and-fill test was also applied to evaluate meta-analysis bias. Results Twenty articles were included in the qualitative analysis, and 6 articles were included in the meta-analysis. Case-control studies showed bias related to exposure, and the main bias in cohort studies were related to selection and outcome. All articles received score 4 for the level of evidence. Hypertension and diabetes were the comorbidities more frequently associated with thrombolytic events. Significant results were found regarding D-dimer (P < .0001) and age (P = .0202) for thrombotic events in patients diagnosed with COVID-19. Conclusion Patients older than 60 years, with hypertension, diabetes and D-Dimer values above 3.17 mu g/mL, can be considered prognostic factors for developing thrombotic events due to COVID-19. (AU)

• Processo FAPESP: 21/01191-0 - Indução de tolerância e caracterização do biofime de Candida albicans submetido à terapia fotodinâmica antimicrobiana
• Beneficiário: Túlio Morandin Ferrisse
• Modalidade de apoio: Bolsas no Brasil - Pós-Doutorado
• Processo FAPESP: 19/08375-0 - Potencialização do efeito anticárie e antibiofilme de substâncias convencionais: avaliação em modelo de biofilme polimicrobiano
• Beneficiário: Fernanda Lourenção Brighenti
• Modalidade de apoio: Auxílio à Pesquisa - Regular
• Processo FAPESP: 19/26066-4 - Sistemas multiparticulados mucoadesivos para liberação controlada de substâncias naturais
• Beneficiário: Luciana Solera Sales
• Modalidade de apoio: Bolsas no Brasil - Doutorado
• Processo FAPESP: 18/18440-0 - Bioprospecção de produtos naturais em terapia fotodinâmica contra micro-organismos de interesse médico-odontológico
• Beneficiário: Analú Barros de Oliveira
• Modalidade de apoio: Bolsas no Brasil - Mestrado
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• Beneficiário: Analú Barros de Oliveira
• Modalidade de apoio: Bolsas no Brasil - Doutorado