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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

COVID-19 (SARS-CoV-2) infection and thrombotic conditions: A systematic review and meta-analysis

Full text
Author(s):
Gabbai-Armelin, Paulo Roberto [1] ; de Oliveira, Analu Barros [1] ; Ferrisse, Tulio Morandin [1] ; Sales, Luciana Solera [1] ; Barbosa, Elis Rodrigues Oliveira [1] ; Miranda, Marina Lins [1] ; Salomao, Karina Borges [1] ; Brighenti, Fernanda Lourencao [1]
Total Authors: 8
Affiliation:
[1] Sao Paulo State Univ Unesp, Sch Dent, BR-14801903 Araraquara, SP - Brazil
Total Affiliations: 1
Document type: Review article
Source: EUROPEAN JOURNAL OF CLINICAL INVESTIGATION; v. 51, n. 6 APR 2021.
Web of Science Citations: 2
Abstract

Background COVID-19 is an infectious disease caused by SARS-CoV-2 associated with haematological manifestations (thrombolytic events). Aims Considering the high prevalence of the thrombotic scenarios associated with COVID-19, the aim of this study was to perform a systematic review of the available literature, concerning the relation of COVID-19 and the thrombotic events, and identify prognostic factors for these events. Materials \& Methods PubMed, Web of Science and Scopus databases were searched. Independent reviewers conducted all flow diagram steps. For qualitative analysis, Oxford level of evidence and Newcastle-Ottawa scale were used in the eligible articles. For the prognostic factors, a meta-analysis was conducted to age, number of neutrophils and platelets, and levels of ferritin, C-reactive protein, lactate dehydrogenase and D-dimer. Publication bias was accessed by funnel plot and by trim-and-fill test. Trim-and-fill test was also applied to evaluate meta-analysis bias. Results Twenty articles were included in the qualitative analysis, and 6 articles were included in the meta-analysis. Case-control studies showed bias related to exposure, and the main bias in cohort studies were related to selection and outcome. All articles received score 4 for the level of evidence. Hypertension and diabetes were the comorbidities more frequently associated with thrombolytic events. Significant results were found regarding D-dimer (P < .0001) and age (P = .0202) for thrombotic events in patients diagnosed with COVID-19. Conclusion Patients older than 60 years, with hypertension, diabetes and D-Dimer values above 3.17 mu g/mL, can be considered prognostic factors for developing thrombotic events due to COVID-19. (AU)

FAPESP's process: 21/01191-0 - Tolerance induction and Candida albicans's biofilm characterization after antimicrobial photodymamic therapy application
Grantee:Túlio Morandin Ferrisse
Support Opportunities: Scholarships in Brazil - Post-Doctoral
FAPESP's process: 19/08375-0 - Maximization of the anti-caries and antibiofilm effect of conventional substances: evaluation in a polymicrobial biofilm model
Grantee:Fernanda Lourenção Brighenti
Support Opportunities: Regular Research Grants
FAPESP's process: 19/26066-4 - Mucoadhesive multiparticulate system for controlled release of natural substances
Grantee:Luciana Solera Sales
Support Opportunities: Scholarships in Brazil - Doctorate
FAPESP's process: 18/18440-0 - Bioprospection of natural products in photodynamic therapy against microorganisms of medial and dental importance
Grantee:Analú Barros de Oliveira
Support Opportunities: Scholarships in Brazil - Master
FAPESP's process: 20/07110-0 - Potential of photodynamic therapy in modulating the inflammatory response and microbial virulence factors: evaluation in a model of three-dimensional co-cultures of gingival fibroblasts, Candida albicans and Staphylococcus aureus
Grantee:Analú Barros de Oliveira
Support Opportunities: Scholarships in Brazil - Doctorate