Mucoadhesive multiparticulate system for controlled release of natural substances

• Grant number: 19/26066-4
• Support Opportunities: Scholarships in Brazil - Doctorate
• Effective date (Start): January 01, 2021
• Effective date (End): December 31, 2023
• Field of knowledge: Health Sciences - Dentistry - Dental Clinics
• Principal Investigator: Fernanda Lourenção Brighenti
• Grantee: Luciana Solera Sales
• Host Institution: Faculdade de Odontologia (FOAr). Universidade Estadual Paulista (UNESP). Campus de Araraquara. Araraquara , SP, Brazil
• Associated scholarship(s): 21/12931-5 - Anti-inflammatory, antioxidant and antimicrobial evaluation of mucoadhesive multiparticulate system containing botanical substance, BE.EP.DR

Abstract

Dental Caries is considered a public health problem worldwide, affecting not only children, but also teenagers and adults. For the disease development, microorganisms must adhere to the tooth surface and form biofilms. Our research group has been studying natural products from plants for the chemical control of oral biofilms. To overcome some limitations of these natural products, a mucoahesive system for controlled release has been developed. The results showed that this system controls biofilms cariogenic factors. However, this system needs to be optimized to improve its applicability in clinical practice. Thus, the present project aims to develop, synthesize and characterize in vitro mucoadhesive multiparticulate system for controlled release of natural substances and to evaluate their anti-caries, antimicrobial, antibiofilm and cytotoxicity activity. The systems will be obtained from natural polymers using two preparation techniques. Further, a flavonoid or a terpene will be added to the systems. A polymicrobial inoculum obtained from saliva of a previously selected volunteer will be used.Sscreening of the antimicrobial and antibiofilm systems activity will be performed. The systems with the best results will be analyzed for their ability to interfere with polymicrobial biofilm maturation, enamel demineralization and cytotoxicity. The systems will also be characterized by in vitro release mechanisms, mucoadhesiveness and surface morphology of the systems. (AU)

Scientific publications

(5)

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

SALES, LUCIANA SOLERA; MIRANDA, MARINA LINS; DE OLIVEIRA, ANALU BARROS; FERRISSE, TULIO MORANDIN; FONTANA, CARLA RAQUEL; MILWARD, MICHAEL; BRIGHENTI, FERNANDA LOURENCAO. Effect of the technique of photodynamic therapy against the main microorganisms responsible for periodontitis: A systematic review of in-vitro studies. ARCHIVES OF ORAL BIOLOGY, v. 138, p. 13-pg., 2022-03-28. (19/26066-4, 21/12931-5, 20/07110-0, 19/08375-0, 21/01191-0)

GABBAI-ARMELIN, PAULO R.; SALES, LUCIANA S.; FERRISSE, TULIO MORANDIN; DE OLIVEIRA, ANALU BARROS; DE OLIVEIRA, JULIANA R.; GIRO, ELISA M. A.; BRIGHENTI, FERNANDA L.. A systematic review and meta-analysis of the effect of thymol as an anti-inflammatory and wound healing agent A review of thymol effect on inflammation and wound healing. Phytotherapy Research, v. 36, n. 9, p. 29-pg., 2022-07-18. (20/07110-0, 19/08375-0, 21/01191-0, 19/26066-4)

THALITA MENDES; LUCIANA SOLERA SALES; MARCELLE DANELON; FERNANDA LOURENÇÃO BRIGHENTI. Seleção de doadores de saliva para crescimento de biofilme in vitro. Rev. odontol. UNESP, v. 52, 2023-12-04. (21/12931-5, 19/26066-4, 19/08375-0)

SALES, LUCIANA SOLERA; GIMENES, MILENA DA SILVA; MENEGUIN, ANDREIA BAGLIOTTI; BARUD, HERNANE DA SILVA; ACHCAR, JORGE ALBERTO; BRIGHENTI, FERNANDA LOURENCAO. Development of multiparticulate systems based on natural polymers for morin controlled release. International Journal of Biological Macromolecules, v. 228, p. 12-pg., 2022-12-23. (19/26066-4, 19/19817-3, 17/50334-3, 21/12931-5, 19/08375-0, 13/07276-1)

GABBAI-ARMELIN, PAULO ROBERTO; DE OLIVEIRA, ANALU BARROS; FERRISSE, TULIO MORANDIN; SALES, LUCIANA SOLERA; BARBOSA, ELIS RODRIGUES OLIVEIRA; MIRANDA, MARINA LINS; SALOMAO, KARINA BORGES; BRIGHENTI, FERNANDA LOURENCAO. COVID-19 (SARS-CoV-2) infection and thrombotic conditions: A systematic review and meta-analysis. EUROPEAN JOURNAL OF CLINICAL INVESTIGATION, v. 51, n. 6, APR 2021. (21/01191-0, 19/08375-0, 19/26066-4, 18/18440-0, 20/07110-0)