Advanced search
Start date
Betweenand

Mucoadhesive multiparticulate system for controlled release of natural substances

Grant number: 19/26066-4
Support type:Scholarships in Brazil - Doctorate
Effective date (Start): January 01, 2021
Effective date (End): June 30, 2023
Field of knowledge:Health Sciences - Dentistry - Dental Clinics
Principal researcher:Fernanda Lourenção Brighenti
Grantee:Luciana Solera Sales
Home Institution: Faculdade de Odontologia (FOAr). Universidade Estadual Paulista (UNESP). Campus de Araraquara. Araraquara , SP, Brazil

Abstract

Dental Caries is considered a public health problem worldwide, affecting not only children, but also teenagers and adults. For the disease development, microorganisms must adhere to the tooth surface and form biofilms. Our research group has been studying natural products from plants for the chemical control of oral biofilms. To overcome some limitations of these natural products, a mucoahesive system for controlled release has been developed. The results showed that this system controls biofilms cariogenic factors. However, this system needs to be optimized to improve its applicability in clinical practice. Thus, the present project aims to develop, synthesize and characterize in vitro mucoadhesive multiparticulate system for controlled release of natural substances and to evaluate their anti-caries, antimicrobial, antibiofilm and cytotoxicity activity. The systems will be obtained from natural polymers using two preparation techniques. Further, a flavonoid or a terpene will be added to the systems. A polymicrobial inoculum obtained from saliva of a previously selected volunteer will be used.Sscreening of the antimicrobial and antibiofilm systems activity will be performed. The systems with the best results will be analyzed for their ability to interfere with polymicrobial biofilm maturation, enamel demineralization and cytotoxicity. The systems will also be characterized by in vitro release mechanisms, mucoadhesiveness and surface morphology of the systems. (AU)

News published in Agência FAPESP Newsletter about the scholarship:
Articles published in other media outlets (0 total):
More itemsLess items
VEICULO: TITULO (DATA)
VEICULO: TITULO (DATA)

Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
GABBAI-ARMELIN, PAULO ROBERTO; DE OLIVEIRA, ANALU BARROS; FERRISSE, TULIO MORANDIN; SALES, LUCIANA SOLERA; BARBOSA, ELIS RODRIGUES OLIVEIRA; MIRANDA, MARINA LINS; SALOMAO, KARINA BORGES; BRIGHENTI, FERNANDA LOURENCAO. COVID-19 (SARS-CoV-2) infection and thrombotic conditions: A systematic review and meta-analysis. EUROPEAN JOURNAL OF CLINICAL INVESTIGATION, v. 51, n. 6 APR 2021. Web of Science Citations: 2.

Please report errors in scientific publications list by writing to: cdi@fapesp.br.