Gastroretentive microparticles containing trans resveratrols nanoparticle applied to the treatment of Helicobacter pylori infections

• Grant number: 19/09597-6
• Support type: Scholarships in Brazil - Doctorate
• Effective date (Start): August 01, 2019
• Effective date (End): July 31, 2023
• Field of knowledge: Health Sciences - Pharmacy - Pharmaceutical Technology
• Principal Investigator: Marlus Chorilli
• Grantee: Larissa Sposito
• Home Institution: Faculdade de Ciências Farmacêuticas (FCFAR). Universidade Estadual Paulista (UNESP). Campus de Araraquara. Araraquara , SP, Brazil

Abstract

Helicobacter pylori infections are considered to be the most prevalent in men and deserve special attention, since they are directly related to severe clinical conditions, such as chronic gastritis, peptic ulcer, and gastric cancer. Several virulence factors and the ability of this bacterium to form biofilms increase resistance to conventional antimicrobials. In this sense, there is a growing interest in the search for new substances, among them of natural origin, as well as new treatment strategies against H. pylori. The development of a gastroretentive polymeric system from nanoparticles incorporated into microparticles that have mucoadhesive and floatage proves to be an interesting strategy for oral administration aiming the vectorization to the gastric region of active substances, such as trans-resveratrol, aiming at its potential application against H. pylori infections. The system proposed in this project will be obtained from the association of biopolymers which aggregate favorable properties to the intended performance, such as particle formation through interaction with polyvalent ions, mucoadhesive, solubility improvement and floatage. In vitro drug release profile assays and in vitro and in vivo antimicrobial activity tests will also be performed. Thus, expected a stable system, gastroretentive and anti-H-pylori effective. (AU)