Gastroretentive microparticles containing trans resveratrol nanoparticles applied to the treatment of Helicobacter pylori infections

• Grant number: 19/09597-6
• Support Opportunities: Scholarships in Brazil - Doctorate
• Start date: August 01, 2019
• End date: April 30, 2024
• Field of knowledge: Health Sciences - Pharmacy - Pharmaceutical Technology
• Principal Investigator: Marlus Chorilli
• Grantee: Larissa Sposito
• Host Institution: Faculdade de Ciências Farmacêuticas (FCFAR). Universidade Estadual Paulista (UNESP). Campus de Araraquara. Araraquara , SP, Brazil
• Associated scholarship(s): 21/11681-5 - Evaluation of the activity of microparticles containing trans-resveratrol nanoparticles against clinical strains of Helicobacter pylori: in vitro study, BE.EP.DR

Abstract

Helicobacter pylori infections are considered to be the most prevalent in men and deserve special attention, since they are directly related to severe clinical conditions, such as chronic gastritis, peptic ulcer, and gastric cancer. Several virulence factors and the ability of this bacterium to form biofilms increase resistance to conventional antimicrobials. In this sense, there is a growing interest in the search for new substances, among them of natural origin, as well as new treatment strategies against H. pylori. The development of a gastroretentive polymeric system from nanoparticles incorporated into microparticles that have mucoadhesive and floatage proves to be an interesting strategy for oral administration aiming the vectorization to the gastric region of active substances, such as trans-resveratrol, aiming at its potential application against H. pylori infections. The system proposed in this project will be obtained from the association of biopolymers which aggregate favorable properties to the intended performance, such as particle formation through interaction with polyvalent ions, mucoadhesive, solubility improvement and floatage. In vitro drug release profile assays and in vitro and in vivo antimicrobial activity tests will also be performed. Thus, it is expected a stable system, gastroretentive and anti-H-pylori effective. (AU)

Scientific publications

(5)

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

SPOSITO, LARISSA; FORTUNATO, GIOVANNA CAPALDI; DE CAMARGO, BRUNA ALMEIDA FURQUIM; RAMOS, MATHEUS APARECIDO DOS SANTOS; DE SOUZA, MAURICIO PALMEIRA CHAVES; MENEGUIN, ANDREIA BAGLIOTTI; BAUAB, TAIS MARIA; CHORILLI, MARLUS. Exploiting drug delivery systems for oral route in the peptic ulcer disease treatment. Journal of Drug Targeting, APR 2021. (19/09597-6)

MARENA, GABRIEL DAVI; DOS SANTOS RAMOS, MATHEUS APARECIDO; CARVALHO, GABRIELA CORREA; DE LIMA, LAURA CAMINITTI; CARNEIRO SOARES DO NASCIMENTO, ANDRE LUIZ; SABIO, RAFAEL MIGUEL; RODERO, CAMILA FERNANDA; SPOSITO, LARISSA; BAUAB, TAIS MARIA; CHORILLI, MARLUS. Development and characterization of an amphotericin B - loaded nanoemulsion applied to Candida auris biofilms control. JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY, v. 74, p. 14-pg., 2022-07-20. (19/26821-7, 18/25377-3, 19/09597-6, 19/09831-9, 18/23442-2, 14/50928-2, 17/22758-3, 18/23357-5)

SPOSITO, LARISSA; FORTUNATO, GIOVANNA CAPALDI; DE CAMARGO, BRUNA ALMEIDA FURQUIM; RAMOS, MATHEUS APARECIDO DOS SANTOS; DE SOUZA, MAURICIO PALMEIRA CHAVES; MENEGUIN, ANDREIA BAGLIOTTI; BAUAB, TAIS MARIA; CHORILLI, MARLUS. Exploiting drug delivery systems for oral route in the peptic ulcer disease treatment. Journal of Drug Targeting, v. 29, n. 10, p. 1029-1047, NOV 26 2021. (19/09597-6)

DE SOUZA, MAURICIO PALMEIRA CHAVES; DE CAMARGO, BRUNA ALMEIDA FURQUIM; SPOSITO, LARISSA; FORTUNATO, GIOVANNA CAPALDI; CARVALHO, GABRIELA CORREA; MARENA, GABRIEL DAVI; MENEGUIN, ANDREIA BAGLIOTTI; BAUAB, TAIS MARIA; CHORILLI, MARLUS. Highlighting the use of micro and nanoparticles based-drug delivery systems for the treatment of Helicobacter pylori infections. CRITICAL REVIEWS IN MICROBIOLOGY, v. 47, n. 4, p. 435-460, JUL 4 2021. (19/09597-6)

MENEGUIN, ANDREIA BAGLIOTTI; SILVESTRE, AMANDA LETICIA POLLI; SPOSITO, LARISSA; DE SOUZA, MAURICIO PALMEIRA CHAVES; SABIO, RAFAEL MIGUEL; ARAUJO, VICTOR HUGO SOUSA; CURY, BEATRIZ STRINGHETTI FERREIRA; CHORILLI, MARLUS. The role of polysaccharides from natural resources to design oral insulin micro- and nanoparticles intended for the treatment of Diabetes mellitus: A review. Carbohydrate Polymers, v. 256, MAR 15 2021. (19/09597-6, 14/50928-2, 19/19817-3)