Micronutrient supplementation needs more attention in patients with refractory epilepsy under ketogenic diet treatment

Autor(es)

Prudencio, Mariana Baldini ^[1] ; de Lima, Patricia Azevedo ^[2] ; Murakami, Daniela Kawamoto ^[3] ; Sampaio, Leticia Pereira de Brito ^[3] ; Damasceno, Nagila Raquel Teixeira ^[1]

Afiliação do(s) autor(es)

^[1] Univ Sao Paulo, Sch Publ Hlth, Dept Nutr, Sao Paulo - Brazil

^[2] Univ Sao Paulo, Program Appl Human Nutr, Fac Pharm, Sao Paulo - Brazil

^[3] Univ Sao Paulo, Childrens Inst, Sch Med, Hosp Clin, Sao Paulo - Brazil

• Tipo de documento: Artigo Científico
• Fonte: NUTRITION; v. 86, JUN 2021.
• Citações Web of Science: 0

Resumo

Objectives: This study evaluated the adequacy of micronutrient intake from the ketogenic diet (KD) with and without micronutrient supplementation according to age in Brazilian children and adolescents with refractory epilepsy undergoing KD treatment. Methods: This study enrolled children and adolescents with refractory epilepsy who were up to 19 y of age. Nutrient intakes were monitored using 3 d food records before introducing micronutrient supplementation and 3 mo after starting KD treatment. The prevalence of micronutrient inadequacy was estimated by sex and age according to the estimated average requirement cutoff values. Results: This study included 39 children and adolescents. The KD did not provide enough content of folate, calcium, and magnesium in all patients according to the dietary reference intake. Even after starting supplementation, calcium, phosphorus, and magnesium intake remained inadequate in the majority of patients. The supplementation effectively met the vitamin B12 recommendation in all age groups. Conclusions: KD treatment did not provide adequate levels of the monitored micronutrients. The supplementation improved but did not prevent the inadequacy of micronutrients such as calcium, magnesium, and phosphorus. The results highlight the importance of individual supplementation protocols and the need to monitor micronutrient intake according to age and sex. (C) 2021 Published by Elsevier Inc. (AU)

• Processo FAPESP: 15/24928-8 - Associação dos ácidos graxos de membranas eritrocitárias com o controle de crises convulsivas em crianças e adolescentes com epilepsia refratária sob o tratamento com dieta cetogênica
• Beneficiário: Giovanna Fernandes Ricciarelli
• Modalidade de apoio: Bolsas no Brasil - Iniciação Científica
• Processo FAPESP: 12/20789-5 - Estudo de inadequação de consumo de macro e micronutrientes em crianças e adolescentes sob tratamento dietético para epilepsia refratária
• Beneficiário: Mariana Baldini Prudencio
• Modalidade de apoio: Bolsas no Brasil - Iniciação Científica
• Processo FAPESP: 14/26094-4 - Dieta cetogênica clássica e modificada: avaliação do potencial terapêutico e impacto sobre o perfil oxidativo, lipidômico, inflamatório e tamanho de lipoproteínas em crianças e adolescentes com epilepsia refratária
• Beneficiário: Patricia Azevedo de Lima
• Modalidade de apoio: Bolsas no Brasil - Doutorado
• Processo FAPESP: 14/50983-3 - INCT 2014: fluidos complexos
• Beneficiário: Antonio Martins Figueiredo Neto
• Modalidade de apoio: Auxílio à Pesquisa - Temático