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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Micronutrient supplementation needs more attention in patients with refractory epilepsy under ketogenic diet treatment

Full text
Author(s):
Prudencio, Mariana Baldini [1] ; de Lima, Patricia Azevedo [2] ; Murakami, Daniela Kawamoto [3] ; Sampaio, Leticia Pereira de Brito [3] ; Damasceno, Nagila Raquel Teixeira [1]
Total Authors: 5
Affiliation:
[1] Univ Sao Paulo, Sch Publ Hlth, Dept Nutr, Sao Paulo - Brazil
[2] Univ Sao Paulo, Program Appl Human Nutr, Fac Pharm, Sao Paulo - Brazil
[3] Univ Sao Paulo, Childrens Inst, Sch Med, Hosp Clin, Sao Paulo - Brazil
Total Affiliations: 3
Document type: Journal article
Source: NUTRITION; v. 86, JUN 2021.
Web of Science Citations: 0
Abstract

Objectives: This study evaluated the adequacy of micronutrient intake from the ketogenic diet (KD) with and without micronutrient supplementation according to age in Brazilian children and adolescents with refractory epilepsy undergoing KD treatment. Methods: This study enrolled children and adolescents with refractory epilepsy who were up to 19 y of age. Nutrient intakes were monitored using 3 d food records before introducing micronutrient supplementation and 3 mo after starting KD treatment. The prevalence of micronutrient inadequacy was estimated by sex and age according to the estimated average requirement cutoff values. Results: This study included 39 children and adolescents. The KD did not provide enough content of folate, calcium, and magnesium in all patients according to the dietary reference intake. Even after starting supplementation, calcium, phosphorus, and magnesium intake remained inadequate in the majority of patients. The supplementation effectively met the vitamin B12 recommendation in all age groups. Conclusions: KD treatment did not provide adequate levels of the monitored micronutrients. The supplementation improved but did not prevent the inadequacy of micronutrients such as calcium, magnesium, and phosphorus. The results highlight the importance of individual supplementation protocols and the need to monitor micronutrient intake according to age and sex. (C) 2021 Published by Elsevier Inc. (AU)

FAPESP's process: 15/24928-8 - Association of fatty acids of erythrocytes membranes with control seizures in children and adolescents with epilepsy refractory under treatment with ketogenic diet
Grantee:Giovanna Fernandes Ricciarelli
Support Opportunities: Scholarships in Brazil - Scientific Initiation
FAPESP's process: 12/20789-5 - Study of inadequate intake of macro and micronutrients in children and adolescents in the dietary treatment for refractory epilepsy
Grantee:Mariana Baldini Prudencio
Support Opportunities: Scholarships in Brazil - Scientific Initiation
FAPESP's process: 14/26094-4 - Diet classic and modified ketogenic: evaluation of the therapeutic potential and impact on the oxidative, lipidomic profile, inflammatory and lipoproteins size in children and adolescents with refractory epilepsy
Grantee:Patricia Azevedo de Lima
Support Opportunities: Scholarships in Brazil - Doctorate
FAPESP's process: 14/50983-3 - INCT 2014: complex fluids
Grantee:Antonio Martins Figueiredo Neto
Support Opportunities: Research Projects - Thematic Grants