Intercostal and vastus lateralis microcirculatory response to a sympathoexcitatory manoeuvre in patients with chronic obstructive pulmonary disease

Autor(es)

Ribeiro, Indyanara C. ^[1] ; Aranda, Liliane C. ^[1] ; Freitas, Tiago O. ^[1] ; Degani-Costa, Luiza H. ^[1] ; Ferreira, Eloara V. M. ^[1] ; Nery, Luiz E. ^[1] ; Silva, Bruno M. ^{[2, 1]}

Afiliação do(s) autor(es)

^[1] Fed Univ Sao Paulo UNIFESP, Div Resp Med, Sao Paulo, SP - Brazil

^[2] Univ Fed Sao Paulo, Dept Physiol, Sao Paulo, SP - Brazil

• Tipo de documento: Artigo Científico
• Fonte: Respiratory Physiology & Neurobiology; v. 290, AUG 2021.
• Citações Web of Science: 0

Resumo

Patients with COPD present with systemic vascular malfunctioning and their microcirculation is possibly more fragile to overcome an increase in the sympathetic vasoconstrictor outflow during sympathoexcitatory situations. To test the skeletal muscle microvascular responsiveness to sympathoexcitation, we asked patients with COPD and age- and sex-matched controls to immerse a hand in iced water {[}Cold Pressor Test (CPT)]. Near-infrared spectroscopy detection of the indocyanine green dye in the intercostal and vastus lateralis microcirculation provided a blood flow index (BFI). BFI divided by mean blood pressure (MBP) provided an index of microvascular conductance (BFI/MBP). The CPT decreased BFI and BFI/MBP in the intercostal (P = 0.01 and < 0.01, respectively) and vastus lateralis (P = 0.08 and 0.03, respectively) only in the COPD group, and the per cent BFI and BFI/MBP decrease was similar between muscles (P = 0.78 and 0.85, respectively). Thus, our findings support that sympathoexcitation similarly impairs intercostal and vastus lateralis microvascular regulation in patients with COPD. (AU)

• Processo FAPESP: 17/07771-3 - Papel de aferências musculares ativadas pelo exercício físico para o controle cardiorrespiratório em pacientes com doença pulmonar obstrutiva crônica
• Beneficiário: Bruno Moreira Silva
• Modalidade de apoio: Auxílio à Pesquisa - Regular