| Full text | |
| Author(s): |
Ribeiro, Indyanara C.
[1]
;
Aranda, Liliane C.
[1]
;
Freitas, Tiago O.
[1]
;
Degani-Costa, Luiza H.
[1]
;
Ferreira, Eloara V. M.
[1]
;
Nery, Luiz E.
[1]
;
Silva, Bruno M.
[2, 1]
Total Authors: 7
|
| Affiliation: | [1] Fed Univ Sao Paulo UNIFESP, Div Resp Med, Sao Paulo, SP - Brazil
[2] Univ Fed Sao Paulo, Dept Physiol, Sao Paulo, SP - Brazil
Total Affiliations: 2
|
| Document type: | Journal article |
| Source: | Respiratory Physiology & Neurobiology; v. 290, AUG 2021. |
| Web of Science Citations: | 0 |
| Abstract | |
Patients with COPD present with systemic vascular malfunctioning and their microcirculation is possibly more fragile to overcome an increase in the sympathetic vasoconstrictor outflow during sympathoexcitatory situations. To test the skeletal muscle microvascular responsiveness to sympathoexcitation, we asked patients with COPD and age- and sex-matched controls to immerse a hand in iced water {[}Cold Pressor Test (CPT)]. Near-infrared spectroscopy detection of the indocyanine green dye in the intercostal and vastus lateralis microcirculation provided a blood flow index (BFI). BFI divided by mean blood pressure (MBP) provided an index of microvascular conductance (BFI/MBP). The CPT decreased BFI and BFI/MBP in the intercostal (P = 0.01 and < 0.01, respectively) and vastus lateralis (P = 0.08 and 0.03, respectively) only in the COPD group, and the per cent BFI and BFI/MBP decrease was similar between muscles (P = 0.78 and 0.85, respectively). Thus, our findings support that sympathoexcitation similarly impairs intercostal and vastus lateralis microvascular regulation in patients with COPD. (AU) | |
| FAPESP's process: | 17/07771-3 - Role of muscle afferents activated by physical exercise for the cardiorespiratory control in patients with chronic obstructive pulmonary disease |
| Grantee: | Bruno Moreira Silva |
| Support Opportunities: | Regular Research Grants |