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Study of pulmonary hemodynamics and cardiac morphofunctional variables secondary to pulmonary emphysema induced by porcine pancretic elastase in dibetic rats

Abstract

Clinical studies in patients with chronic obstructive pulmonary disease (COPD) showed that structural and functional alterations of the lung microcirculation are major factors for the development of pulmonary hypertension and right ventricular hypertrophy during COPD-associated hypoxemia. In addition, pulmonary microcirculatory dysfunctions associated with diabetes mellitus increase the gravity of the ongoing COPD. The present study aims to investigate pulmonary hemodynamics and cardiac morphofunctional variables secondary to pulmonary emphysema induced by porcine pancreatic elastase in diabetic rats. The study design includes: 1) echocardiographic analysis; 2) body weight/heart weight ratio: 3) heart morphometric analysis; 4) histological and morphometric analyses of lung parenchyma; 5) quantitative analysis of elastic fibers; 6) quantitative analysis of collagen fibers; 7) pulmonary hemodynamics: ex vivo functional evaluation: 8) arterial blood gases and electrolytes. (AU)

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