| Grant number: | 17/07771-3 |
| Support Opportunities: | Regular Research Grants |
| Duration: | December 01, 2017 - November 30, 2020 |
| Field of knowledge: | Biological Sciences - Physiology - General Physiology |
| Principal Investigator: | Bruno Moreira Silva |
| Grantee: | Bruno Moreira Silva |
| Host Institution: | Escola Paulista de Medicina (EPM). Universidade Federal de São Paulo (UNIFESP). Campus São Paulo. São Paulo , SP, Brazil |
| Associated researchers: | Acary Souza Bulle Oliveira ; Flávio Ferlin Arbex ; Gerhardus Hermanus Maria Schoorlemmer ; Indyanara Cristina Ribeiro ; Lauro Casqueiro Vianna ; Liliane Cunha Aranda ; Luiz Eduardo Nery ; Luiza Helena Degani Costa ; Patricia Chakur Brum ; Priscila Cristina de Abreu Sperandio ; Roberta Pulcheri Ramos ; Tiago Obeid de Freitas |
Abstract
Patients with chronic obstructive pulmonary disease (COPD) have exercise intolerance, which is characterized by ventilatory limitation and dyspnea, as well as by skeletal muscle dysfunction (reduction of strength, endurance and muscle mass). Given that the cardiorespiratory responses to exercise are partly determined by reflexes triggered by activation of type III and IV afferents in skeletal muscles, it is plausible that the muscle dysfunction in COPD is accompanied by altered muscle reflexes, which, however, is still unclear. Therefore, the purpose this project is to investigate the role of muscles afferents activated by physical exercise for the cardiorespiratory control in patients with COPD. In addition, molecular mechanisms presumably involved in the activation of muscle afferents in patients with COPD will be investigated, based on the analysis of the gene expression of enzymes, channels, and receptors in a sample of muscle tissue collected by biopsy. Finally, the association between cardiorespiratory responses generated by the activation of muscle afferents, and the gene expression of mechanisms involved in the activation of muscle afferents, with physical exercise capacity, dyspnea, and quality of life will be investigated. Therefore, the information generated may contribute to enlighten the understanding of the pathophysiology of exercise intolerance in patients with COPD, which then may guide, for example, specific pharmacological treatment and rehabilitation with emphasis on exercise training. (AU)
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